O00299: Chloride intracellular channel protein 1

General Information

Protein names	- Chloride intracellular channel protein 1 - Chloride channel ABP - Nuclear chloride ion channel 27 - NCC27 - Regulatory nuclear chloride ion channel protein - hRNCC
Gene names	CLIC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00299

10 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP
        70         80         90        100        110        120
GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN
       130        140        150        160        170        180
SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL
       190        200        210        220        230        240
LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL

K

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00299-2-unknown	MAEEQP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00299-2-Acetylation	AEEQPQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00299-2-Acetylation	AEEQPQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00299-2-Acetylation	AEEQPQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O00299-2-Acetylation	AEEQPQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00299-2-Acetylation	AEEQPQ...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O00299-4-unknown	EQPQVE...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18201
O00299-4-unknown	EQPQVE...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16857
O00299-98-	ALNPES...	98			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00299-103-unknown	SNTAGL...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18202
O00299-105-unknown	TAGLDI...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13694
O00299-142-	NYLTSP...	142			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00299-146-unknown	SPLPEE...	146		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5098
O00299-155-	TSAEDE...	155			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O00299-226-unknown	DEEIEL...	226		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10636

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ALNPES	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18202
...NPESNT	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13694
...DNYLTS	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5098
...STCPDD	225	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10636
...AKALK	241	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AKALK	241		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AKALK	241		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	3	MAEE.\|.EQPQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	3	MAEE.\|.EQPQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	102	NPES.\|.SNTA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	104	ESNT.\|.TAGL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	145	YLTS.\|.SPLP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	225	CPDD.\|.DEEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)