O43583: Density-regulated protein

General Information

Protein names	- Density-regulated protein - DRP - Protein DRP1 - Smooth muscle cell-associated protein 3 - SMAP-3
Gene names	DENR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43583

6 N-termini

3 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN
        70         80         90        100        110        120
FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI
       130        140        150        160        170        180
PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE
       190
KWPEVDDDSI EDLGEVKK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43583-2-unknown	MAADIS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43583-2-Acetylation	AADISE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43583-2-Acetylation	AADISE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O43583-2-Acetylation	AADISE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O43583-2-Acetylation	AADISE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43583-2-Acetylation	AADISE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O43583-3-acetylation	ADISES...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O43583-5-unknown	ISESSG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10763
O43583-9-unknown	SGADCK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10764
O43583-9-unknown	SGADCK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13752
O43583-77-unknown	EAGISE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18238
O43583-77-unknown	EAGISE...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16888

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DISESS	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10764
...DISESS	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13752
...NSPKQE	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18238
...NSPKQE	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16888
...GEVKK	198	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	4	AADI.\|.ISES	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	8	SESS.\|.SGAD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	8	SESS.\|.SGAD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	76	PKQE.\|.EAGI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	76	PKQE.\|.EAGI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)