Q9UMS4: Pre-mRNA-processing factor 19 {ECO:0000305}

General Information

Protein names	- Pre-mRNA-processing factor 19 {ECO:0000305} - 2.3.2.27 {ECO:0000269\|PubMed:11435423} - Nuclear matrix protein 200 {ECO:0000303\|PubMed:11082287} - PRP19/PSO4 homolog {ECO:0000303\|PubMed:12960389} - hPso4 {ECO:0000303\|PubMed:12960389} - RING-type E3 ubiquitin transferase PRP19 {ECO:0000305} - Senescence evasion factor {ECO:0000303\|PubMed:16332694}
Gene names	PRPF19
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UMS4

11 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP
        70         80         90        100        110        120
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL
       130        140        150        160        170        180
TKEVTAAREA LATLKPQAGL IVPQAVPSSQ PSVVGAGEPM DLGELVGMTP EIIQKLQDKA
       190        200        210        220        230        240
TVLTTERKKR GKTVPEELVK PEELSKYRQV ASHVGLHSAS IPGILALDLC PSDTNKILTG
       250        260        270        280        290        300
GADKNVVVFD KSSEQILATL KGHTKKVTSV VFHPSQDLVF SASPDATIRI WSVPNASCVQ
       310        320        330        340        350        360
VVRAHESAVT GLSLHATGDY LLSSSDDQYW AFSDIQTGRV LTKVTDETSG CSLTCAQFHP
       370        380        390        400        410        420
DGLIFGTGTM DSQIKIWDLK ERTNVANFPG HSGPITSIAF SENGYYLATA ADDSSVKLWD
       430        440        450        460        470        480
LRKLKNFKTL QLDNNFEVKS LIFDQSGTYL ALGGTDVQIY ICKQWTEILH FTEHSGLTTG
       490        500
VAFGHHAKFI ASTGMDRSLK FYSL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UMS4-2-unknown	MSLICS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UMS4-2-Acetylation	SLICSI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UMS4-2-Acetylation	SLICSI...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9UMS4-6-	SISNEV...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UMS4-38-	GTDPIN...	38			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UMS4-38-	GTDPIN...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UMS4-38-	GTDPIN...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UMS4-82-unknown	WDAVML...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4297
Q9UMS4-86-unknown	MLHSFT...	86		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446259
Q9UMS4-172-unknown	IIQKLQ...	172		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443031
Q9UMS4-191-	GKTVPE...	191			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UMS4-191-	GKTVPE...	191			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9UMS4-197-unknown	ELVKPE...	197		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19861
Q9UMS4-329-unknown	YWAFSD...	329		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445435
Q9UMS4-387-unknown	NFPGHS...	387		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8148

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ALQDEW	81	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4297
...TERKKR	189	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446259
...KTVPEE	196	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19861
...RTNVAN	386	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8148
...KFYSL	504	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KFYSL	504		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KFYSL	504		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KFYSL	504		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KFYSL	504		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	81	QDEW.\|.WDAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	196	VPEE.\|.ELVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	386	NVAN.\|.NFPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)