P58107: Epiplakin {ECO:0000303|PubMed:11278896}
| Protein names | - Epiplakin {ECO:0000303|PubMed:11278896} - 450 kDa epidermal antigen |
|---|---|
| Gene names | EPPK1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P58107 |
5
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA SGQAQSVYAA
70 80 90 100 110 120
MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ QGLVGLELKE KLLAAERATT
130 140 150 160 170 180
GYPDPYGGEK LALFQAIGKE VVDRALGQSW LEVQLATGGL VDPAQGVLVA PEPACHQGLL
190 200 210 220 230 240
DRETWHKLSE LEPGTGDLRF LDPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG
250 260 270 280 290 300
AVSAAELLEV GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS
310 320 330 340 350 360
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP ELHEQLLVAE
370 380 390 400 410 420
QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA TGGLVCPARR LRLPLEAALR
430 440 450 460 470 480
CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ LLALCVTDPE TGLAFLPLSG GPRGGEPQGP
490 500 510 520 530 540
PFIKYSTRQA LSTATATVSV GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK
550 560 570 580 590 600
LAAKLSATLE QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA
610 620 630 640 650 660
SVQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT GFIIDPKANK
670 680 690 700 710 720
GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI SLFQAMQKGL IVREHGIRLL
730 740 750 760 770 780
EAQIATGGVI DPVHSHRVPV DVAYRRGYFD QMLNLILLDP SDDTKGFFDP NTHENLTYLQ
790 800 810 820 830 840
LLERCVRDPE TGLYLLPLSS TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE
850 860 870 880 890 900
YFSEGRRRQL LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ
910 920 930 940 950 960
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM RQKLLGPRVA
970 980 990 1000 1010 1020
LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR LKRAEGAIAG FRDPFSGKQV
1030 1040 1050 1060 1070 1080
SVFQAMKKGL IPWEQAARLL EAQVATGGII DPTSHHHLPM PVAIQRGYVD QEMETALSSS
1090 1100 1110 1120 1130 1140
SETFPTPDGQ GRTSYAQLLE ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD
1150 1160 1170 1180 1190 1200
GTSLWDLLSS CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR
1210 1220 1230 1240 1250 1260
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG VLLQPSGAKA
1270 1280 1290 1300 1310 1320
SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV EDAVKVGLVG RELSEQLGQA
1330 1340 1350 1360 1370 1380
ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC
1390 1400 1410 1420 1430 1440
RLGLLDTQTS QVLTAVDKDN KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL
1450 1460 1470 1480 1490 1500
EVDDHTAVAL RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ
1510 1520 1530 1540 1550 1560
VVSAVTTLVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG TTTVKEVAEM
1570 1580 1590 1600 1610 1620
DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT ALVLLEAQAA TGFIIDPVEN
1630 1640 1650 1660 1670 1680
RKLTVEEAFK AGMFGKETYV KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL
1690 1700 1710 1720 1730 1740
LEAQIATGGI IDPVHSHRVP VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL
1750 1760 1770 1780 1790 1800
QLLERCVEDP ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL
1810 1820 1830 1840 1850 1860
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI RGEVTAADLF
1870 1880 1890 1900 1910 1920
NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSGCIA GVTVPSTREV MSLHEASRKE
1930 1940 1950 1960 1970 1980
LIPAAFATWL LEAQAATGFL LDPCTRQKLS VDEAVDVGLV NEELRERLLK AERAATGYRD
1990 2000 2010 2020 2030 2040
PATGDTIPLF QAMQKQLIEK AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI
2050 2060 2070 2080 2090 2100
YALISDQKHM RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW LLFPVNKAAR DSEHIDDETR
2110 2120 2130 2140 2150 2160
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA LQTVAQLILE
2170 2180 2190 2200 2210 2220
LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL ETGRSTTQEL MEDDRVKRYL
2230 2240 2250 2260 2270 2280
EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR
2290 2300 2310 2320 2330 2340
LSVEEAVAAG VVGGEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE
2350 2360 2370 2380 2390 2400
AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL
2410 2420 2430 2440 2450 2460
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ SVSVWELLFY
2470 2480 2490 2500 2510 2520
REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA RAEAEAGSPR PDPREALRAA
2530 2540 2550 2560 2570 2580
TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR EELLAEFGSG TLDLPALTRR LTAIIEEAEE
2590 2600 2610 2620 2630 2640
APGARPQLQD AWRGPREPGP AGRGDGDSGR SQREGQGEGE TQEAAAAAAA AAARRQEQTL
2650 2660 2670 2680 2690 2700
RDATMEVQRG QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE
2710 2720 2730 2740 2750 2760
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD SVKRYLEGTS
2770 2780 2790 2800 2810 2820
CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE AQAATGFVID PVRNLRLSVE
2830 2840 2850 2860 2870 2880
EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY TGQQISLFQA MQKDLIVREH GIRLLEAQIA
2890 2900 2910 2920 2930 2940
TGGVIDPVHS HRVPVDVAYQ RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC
2950 2960 2970 2980 2990 3000
VPDPDTGLYM LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS
3010 3020 3030 3040 3050 3060
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR EALRAATMEV
3070 3080 3090 3100 3110 3120
KVGRLRGRAV PVWDVLASGY VSRAAREELL AEFGSGTLDL PALTRRLTAI IEEAEEAPGA
3130 3140 3150 3160 3170 3180
RPQLQDAWRG PREPGPAGRG DGDSGRSQRE GQGEGETQEA AAAARRQEQT LRDATMEVQR
3190 3200 3210 3220 3230 3240
GQFQGRPVSV WDVLFSSYLS EARRDELLAQ HAAGALGLPD LVAVLTRVIE ETEERLSKVS
3250 3260 3270 3280 3290 3300
FRGLRCQVSA SELHTSGILG PETLRDLAQG TKTLQEVTEM DSVKRYLEGT SCIAGVLVPA
3310 3320 3330 3340 3350 3360
KDQPGRQEKM SIYQAMWKGV LRPGTALVLL EAQAATGFVI DPVRNLRLSV EEAVAAGVVG
3370 3380 3390 3400 3410 3420
GEIQEKLLSA ERAVTGYTDP YTGQQISLFQ AMQKDLIVRE HGIRLLEAQI ATGGVIDPVH
3430 3440 3450 3460 3470 3480
SHRVPVDVAY RRGYFDEEMN RVLADPSDDT KGFFDPNTHE NLTYVQLLRR CVPDPDTGLY
3490 3500 3510 3520 3530 3540
MLQLAGRGSA VHQLSEELRC ALRDARVTPG SGALQGQSVS VWELLFYREV SEDRRQDLLS
3550 3560 3570 3580 3590 3600
RYRAGTLTVE ELGATLTSLL AQAQAQARAE AEAGSPRPDP REALRAATME VKVGRLRGRA
3610 3620 3630 3640 3650 3660
VPVWDVLASG YVSRAAREEL LAEFGSGTLD LPALTRRLTA IIEEAEEAPG ARPQLQDAWR
3670 3680 3690 3700 3710 3720
GPREPGPAGR GDGDSGRSQR EGQGEGETQE AAAATAAARR QEQTLRDATM EVQRGQFQGR
3730 3740 3750 3760 3770 3780
PVSVWDVLFS SYLSEARRDE LLAQHAAGAL GLPDLVAVLT RVIEETEERL SKVSFRGLRR
3790 3800 3810 3820 3830 3840
QVSASELHTS GILGPETLRD LAQGTKTLQE VTEMDSVKRY LEGTSCIAGV LVPAKDQPGR
3850 3860 3870 3880 3890 3900
QEKMSIYQAM WKGVLRPGTA LVLLEAQAAT GFVIDPVRNL RLSVEEAVAA GVVGGEIQEK
3910 3920 3930 3940 3950 3960
LLSAERAVTG YTDPYTGQQI SLFQAMQKDL IVREHGIRLL EAQIATGGVI DPVHSHRVPV
3970 3980 3990 4000 4010 4020
DVAYRRGYFD EEMNRVLADP SDDTKGFFDP NTHENLTYVQ LLRRCVPDPD TGLYMLQLAG
4030 4040 4050 4060 4070 4080
RGSAVHQLSE ELRCALRDAR VTPGSGALQG QSVSVWELLF YREVSEDRRQ DLLSRYRAGT
4090 4100 4110 4120 4130 4140
LTVEELGATL TSLLAQAQAQ ARAEAEAGSP RPDPREALRA ATMEVKVGRL RGRAVPVWDV
4150 4160 4170 4180 4190 4200
LASGYVSRAA REELLAEFGS GTLDLPALTR RLTAIIEEAE EAPGARPQLQ DAWRGPREPG
4210 4220 4230 4240 4250 4260
PAGRGDGDSG RSQREGQGEG ETQEAAAATA AARRQEQTLR DATMEVQRGQ FQGRPVSVWD
4270 4280 4290 4300 4310 4320
VLFSSYLSEA RRDELLAQHA AGALGLPDLV AVLTRVIEET EERLSKVSFR GLRRQVSASE
4330 4340 4350 4360 4370 4380
LHTSGILGPE TLRDLAQGTK TLQEVTEMDS VKRYLEGTSC IAGVLVPAKD QPGHQEKMSI
4390 4400 4410 4420 4430 4440
YQAMWKGVLR PGTALVLLEA QAATGFVIDP VRNLRLSVEE AVAAGVVGGE IQEKLLSAER
4450 4460 4470 4480 4490 4500
AVTGYTDPYT GQQISLFQAM QKDLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR
4510 4520 4530 4540 4550 4560
GYFDEEMNRV LAHPSDDTKG FFDPNTHENL TYVQLLRRCV PDPDTGLYML QLAGRGSAVH
4570 4580 4590 4600 4610 4620
QLSEELRCAL RDARVMPGSG ALQGQSVSVW ELLFYREVSE DRRQDLLSRY RAGTLTVEEL
4630 4640 4650 4660 4670 4680
GATLTSLLAQ AQAQARAEAE AEAGSPRPDP REALRAATME VKVGRLRGRA VPVWDVLASG
4690 4700 4710 4720 4730 4740
YVSGAAREEL LAEFGSGTLD LPALTRRLTA IIEEAEEAPG ARPQLQDAWR GPREPGPAGR
4750 4760 4770 4780 4790 4800
GDGDSGRSQR EGQGEGETQE AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL
4810 4820 4830 4840 4850 4860
SEAHRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS ASELHTSGIL
4870 4880 4890 4900 4910 4920
GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP AKDQPGRQEK MSIYQAMWKG
4930 4940 4950 4960 4970 4980
VLRPGTALVL LEAQAATGFV IDPVRNLRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD
4990 5000 5010 5020 5030 5040
PYTGQQISLF QAMQKDLIVR EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM
5050 5060 5070 5080
NRVLADPSDD TKGFFDPNTH ENLTYLQLLQ RATLDPETGL LFLSLSLQ
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P58107-1-unknown | MSGHTL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P58107-2056-unknown | DPNTQE... | 2056 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17754 | |||
| P58107-2404-unknown | CVPDPD... | 2404 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19224 | |||
| P58107-2505-unknown | EAGSPR... | 2505 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19225 | |||
| P58107-2922-unknown | FFDPNT... | 2922 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19226 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RKRFVD | 2055 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17754 | |||
| ...QLLRRC | 2403 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19224 | |||
| ...ARAEAE | 2504 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19225 | |||
| ...DDTKGF | 2921 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19226 | |||
| ...SLQ | 5090 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MEP1A_HUMAN | 2055 | RFVD.|.DPNT | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
| MEP1B_HUMAN | 2403 | LRRC.|.CVPD | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
| MEP1B_HUMAN | 2504 | AEAE.|.EAGS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
| MEP1B_HUMAN | 2921 | TKGF.|.FFDP | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|