P18075: Bone morphogenetic protein 7

General Information

Protein names	- Bone morphogenetic protein 7 - BMP-7 - Osteogenic protein 1 - OP-1 - Eptotermin alfa
Gene names	BMP7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18075

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS
        70         80         90        100        110        120
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS
       130        140        150        160        170        180
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY
       190        200        210        220        230        240
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR
       250        260        270        280        290        300
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS
       310        320        330        340        350        360
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE
       370        380        390        400        410        420
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY
       430
RNMVVRACGC H

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P18075-30-unknown	DFSLDN...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P18075-136-unknown	FVNLVE...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17413
P18075-136-unknown	FVNLVE...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18818
P18075-293-unknown	STGSKQ...	293	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P18075-300-unknown	SQNRSK...	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16315

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DMVMSF	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17413
...DMVMSF	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18818
...GSKQRS	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16315
...MNATNH	375	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390814
...ACGCH	431	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	135	VMSF.\|.FVNL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	135	VMSF.\|.FVNL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
KLK4_HUMAN	299	KQRS.\|.SQNR	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)