Q06481: Amyloid-like protein 2

General Information

Protein names	- Amyloid-like protein 2 - APLP-2 - APPH - Amyloid protein homolog - CDEI box-binding protein - CDEBP
Gene names	APLP2
Organism	Homo sapiens
Protease Family
Protease ID	I02.016
Chromosome location
UniProt ID	Q06481

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Amyloid-like protein 2 - Isoform 3 of Amyloid-like protein 2 - Isoform 4 of Amyloid-like protein 2 - Isoform 5 of Amyloid-like protein 2 - Isoform 6 of Amyloid-like protein 2

Sequence View

        10         20         30         40         50         60
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
        70         80         90        100        110        120
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
       130        140        150        160        170        180
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
       190        200        210        220        230        240
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
       250        260        270        280        290        300
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
       310        320        330        340        350        360
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
       370        380        390        400        410        420
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
       430        440        450        460        470        480
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
       490        500        510        520        530        540
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
       550        560        570        580        590        600
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
       610        620        630        640        650        660
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
       670        680        690        700        710        720
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
       730        740        750        760
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI         10         20         30         40         50         60
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
        70         80         90        100        110        120
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
       130        140        150        160        170        180
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
       190        200        210        220        230        240
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
       250        260        270        280        290        300
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
       310        320        330        340        350        360
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
       370        380        390        400        410        420
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
       430        440        450        460        470        480
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
       490        500        510        520        530        540
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
       550        560        570        580        590        600
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
       610        620        630        640        650        660
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
       670        680        690        700        710        720
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
       730        740        750        760
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI         10         20         30         40         50         60
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
        70         80         90        100        110        120
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
       130        140        150        160        170        180
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
       190        200        210        220        230        240
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
       250        260        270        280        290        300
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
       310        320        330        340        350        360
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
       370        380        390        400        410        420
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
       430        440        450        460        470        480
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
       490        500        510        520        530        540
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
       550        560        570        580        590        600
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
       610        620        630        640        650        660
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
       670        680        690        700        710        720
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
       730        740        750        760
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI         10         20         30         40         50         60
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
        70         80         90        100        110        120
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
       130        140        150        160        170        180
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
       190        200        210        220        230        240
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
       250        260        270        280        290        300
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
       310        320        330        340        350        360
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
       370        380        390        400        410        420
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
       430        440        450        460        470        480
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
       490        500        510        520        530        540
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
       550        560        570        580        590        600
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
       610        620        630        640        650        660
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
       670        680        690        700        710        720
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
       730        740        750        760
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI         10         20         30         40         50         60
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
        70         80         90        100        110        120
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK
       130        140        150        160        170        180
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT
       190        200        210        220        230        240
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF
       250        260        270        280        290        300
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
       310        320        330        340        350        360
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
       370        380        390        400        410        420
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
       430        440        450        460        470        480
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ
       490        500        510        520        530        540
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
       550        560        570        580        590        600
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
       610        620        630        640        650        660
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD
       670        680        690        700        710        720
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ
       730        740        750        760
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q06481-1-unknown	MAATGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67234
Q06481-1-unknown	MAATGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67235
Q06481-1-unknown	MAATGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67236
Q06481-1-unknown	MAATGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67237
Q06481-32-unknown	GYIEAL...	32	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q06481-32-unknown	GYIEAL...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114911
Q06481-32-unknown	GYIEAL...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114912
Q06481-32-unknown	GYIEAL...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114913
Q06481-32-unknown	GYIEAL...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114914
Q06481-141-unknown	DVLLVP...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19357
Q06481-141-unknown	DVLLVP...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144360
Q06481-141-unknown	DVLLVP...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144361
Q06481-141-unknown	DVLLVP...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144362
Q06481-141-unknown	DVLLVP...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144791
Q06481-165-unknown	HWHTVV...	165	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q06481-165-unknown	HWHTVV...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197765
Q06481-165-unknown	HWHTVV...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197766
Q06481-165-unknown	HWHTVV...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197767
Q06481-165-unknown	HWHTVV...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197764
Q06481-180-unknown	TLYSYG...	180	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q06481-180-unknown	TLYSYG...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197885
Q06481-180-unknown	TLYSYG...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197886
Q06481-180-unknown	TLYSYG...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197887
Q06481-180-unknown	TLYSYG...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197884

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GEFVSD	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19357
...GEFVSD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127622
...GEFVSD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127623
...GEFVSD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127624
...GEFVSD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128066
...EQMQI	763	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EQMQI	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62855
...EQMQI	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62854
...EQMQI	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62852
...EQMQI	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62853
...EQMQI	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62856

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	140	FVSD.\|.DVLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)