Q1KMD3: Heterogeneous nuclear ribonucleoprotein U-like protein 2

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein U-like protein 2 - Scaffold-attachment factor A2 - SAF-A2
Gene names	HNRNPUL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q1KMD3

10 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGPGGACKAE
        70         80         90        100        110        120
PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA QALGQAAQPP PEPPEAAAME
       130        140        150        160        170        180
AAAEPDASEK PAEATAGSGG VNGGEEQGLG KREEDEPEER SGDETPGSEV PGDKAAEEQG
       190        200        210        220        230        240
DDQDSEKSKP AGSDGERRGV KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE
       250        260        270        280        290        300
EDQTLVNLDT YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ
       310        320        330        340        350        360
NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE FGQTFGENDV
       370        380        390        400        410        420
IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL PHVLCKNCVV ELNFGQKEEP
       430        440        450        460        470        480
FFPPPEEFVF IHAVPVEERV RTAVPPKTIE ECEVILMVGL PGSGKTQWAL KYAKENPEKR
       490        500        510        520        530        540
YNVLGAETVL NQMRMKGLEE PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV
       550        560        570        580        590        600
YNSGQRRKLL LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE
       610        620        630        640        650        660
KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN RQNRSRGQGY
       670        680        690        700        710        720
VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR FYGRDYEYNR YRDYYRQYNR
       730        740
DWQSYYYHHP QDRDRYYRNY YGYQGYR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q1KMD3-1-unknown	MEVKRL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q1KMD3-1-acetylation	MEVKRL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q1KMD3-38-unknown	DAEMLE...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14544
Q1KMD3-127-unknown	ASEKPA...	127			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q1KMD3-127-	ASEKPA...	127			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q1KMD3-128-	SEKPAE...	128			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q1KMD3-486-unknown	AETVLN...	486		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19610
Q1KMD3-497-	GLEEPE...	497			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q1KMD3-497-	GLEEPE...	497			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q1KMD3-607-	EVTYGE...	607			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q1KMD3-611-	GELEKE...	611			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LQEALD	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14544
...YNVLGA	485	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19610
...YQGYR	747	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	37	EALD.\|.DAEM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	485	VLGA.\|.AETV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)