Q15019: Septin-2

General Information

Protein names	- Septin-2 - Neural precursor cell expressed developmentally down-regulated protein 5 - NEDD-5
Gene names	SEPT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15019

10 N-termini

16 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Septin-2 - Isoform 3 of Septin-2

Sequence View

        10         20         30         40         50         60
MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK STLINSLFLT
        70         80         90        100        110        120
DLYPERVIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV DTPGYGDAIN CRDCFKTIIS
       130        140        150        160        170        180
YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL KPLDVAFMKA IHNKVNIVPV
       190        200        210        220        230        240
IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV
       250        260        270        280        290        300
GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR
       310        320        330        340        350        360
SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG DGDGGALGHH

V         10         20         30         40         50         60
MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK STLINSLFLT
        70         80         90        100        110        120
DLYPERVIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV DTPGYGDAIN CRDCFKTIIS
       130        140        150        160        170        180
YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL KPLDVAFMKA IHNKVNIVPV
       190        200        210        220        230        240
IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV
       250        260        270        280        290        300
GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR
       310        320        330        340        350        360
SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG DGDGGALGHH

V

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 16 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15019-1-unknown	MSKQQP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15019-1-unknown	MSKQQP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97272
Q15019-2-acetylation	SKQQPT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15019-2-acetylation	SKQQPT...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15019-2-acetylation	SKQQPT...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162964
Q15019-20-	FANLPN...	20			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15019-20-unknown	FANLPN...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178475
Q15019-41-unknown	MVVGES...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397195
Q15019-41-unknown	MVVGES...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386001
Q15019-41-unknown	MVVGES...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000384525
Q15019-41-unknown	MVVGES...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399195
Q15019-41-unknown	MVVGES...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195899
Q15019-56-unknown	SLFLTD...	56		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176590
Q15019-56-	SLFLTD...	56			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15019-146-unknown	VHCCFY...	146		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408296
Q15019-146-unknown	VHCCFY...	146		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197598
Q15019-313-unknown	NEDMNK...	313		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17949
Q15019-313-unknown	NEDMNK...	313		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19543
Q15019-313-unknown	NEDMNK...	313		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150898
Q15019-314-unknown	EDMNKD...	314		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17951
Q15019-314-unknown	EDMNKD...	314		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19545
Q15019-314-unknown	EDMNKD...	314		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150915

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VGFANL	22	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404417
...VGFANL	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153684
...SGLGKS	50	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389174
...SGLGKS	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153893
...LGKSTL	52	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409596
...LGKSTL	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153907
...VIPGAA	71	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413031
...VIPGAA	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154054
...IPGAAE	72	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404484
...IPGAAE	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154067
...DTPGYG	105	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399767
...DTPGYG	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154431
...ERYLHD	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412434
...ERYLHD	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154733
...DESGLN	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394666
...DESGLN	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154799
...NRVHCC	148	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406181
...NRVHCC	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154933
...GHGLKP	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399195
...GHGLKP	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155112
...KAIHNK	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391717
...KAIHNK	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155304
...DTLTLK	189	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408902
...DTLTLK	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155504
...EDEDFK	224	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397195
...GRKVEN	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17949
...GRKVEN	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19543
...GRKVEN	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134300
...RKVENE	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17951
...RKVENE	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19545
...RKVENE	313	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134317
...LGHHV	361	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGHHV	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84895

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	312	KVEN.\|.NEDM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	312	KVEN.\|.NEDM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	313	VENE.\|.EDMN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	313	VENE.\|.EDMN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)