Q9H307: Pinin

General Information

Protein names	- Pinin - 140 kDa nuclear and cell adhesion-related phosphoprotein - Desmosome-associated protein - Domain-rich serine protein - DRS protein - DRSP - Melanoma metastasis clone A protein - Nuclear protein SDK3 - SR-like protein
Gene names	PNN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H307

14 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVAVRTLQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP GGGRGRGSLL
        70         80         90        100        110        120
LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES DPEDDDVKKP ALQSSVVATS
       130        140        150        160        170        180
KERTRRDLIQ DQNMDEKGKQ RNRRIFGLLM GTLQKFKQES TVATERQKRR QEIEQKLEVQ
       190        200        210        220        230        240
AEEERKQVEN ERRELFEERR AKQTELRLLE QKVELAQLQE EWNEHNAKII KYIRTKTKPH
       250        260        270        280        290        300
LFYIPGRMCP ATQKLIEESQ RKMNALFEGR RIEFAEQINK MEARPRRQSM KEKEHQVVRN
       310        320        330        340        350        360
EEQKAEQEEG KVAQREEELE ETGNQHNDVE IEEAGEEEEK EIAIVHSDAE KEQEEEEQKQ
       370        380        390        400        410        420
EMEVKMEEET EVRESEKQQD SQPEEVMDVL EMVENVKHVI ADQEVMETNR VESVEPSENE
       430        440        450        460        470        480
ASKELEPEME FEIEPDKECK TLSPGKENVS ALDMEKESEE KEEKESEPQP EPVAQPQPQS
       490        500        510        520        530        540
QPQLQLQSQS QPVLQSQPPS QPEDLSLAVL QPTPQVTQEQ GHLLPERKDF PVESVKLTEV
       550        560        570        580        590        600
PVEPVLTVHP ESKSKTKTRS RSRGRARNKT SKSRSRSSSS SSSSSSSTSS SSGSSSSSGS
       610        620        630        640        650        660
SSSRSSSSSS SSTSGSSSRD SSSSTSSSSE SRSRSRGRGH NRDRKHRRSV DRKRRDTSGL
       670        680        690        700        710
ERSHKSSKGG SSRDTKGSKD KNSRSDRKRS ISESSRSGKR SSRSERDRKS DRKDKRR

Isoforms

- Isoform 2 of Pinin

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H307-2-unknown	MAVAVR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H307-2-Acetylation	AVAVRT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H307-10-unknown	EQLEKA...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19796
Q9H307-10-unknown	EQLEKA...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18124
Q9H307-134-unknown	MDEKGK...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85249
Q9H307-391-unknown	EMVENV...	391		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14993
Q9H307-391-unknown	EMVENV...	391		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148744
Q9H307-413-unknown	SVEPSE...	413		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176104
Q9H307-413-	SVEPSE...	413			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H307-506-unknown	SLAVLQ...	506		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171450
Q9H307-506-	SLAVLQ...	506			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H307-508-unknown	AVLQPT...	508		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173905
Q9H307-508-	AVLQPT...	508			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H307-534-	SVKLTE...	534			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H307-534-	SVKLTE...	534			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H307-534-unknown	SVKLTE...	534		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176910
Q9H307-540-unknown	VPVEPV...	540		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18125
Q9H307-540-unknown	VPVEPV...	540		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152121

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRTLQE	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19796
...VRTLQE	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18124
...VMDVLE	390	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14993
...VMDVLE	390	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132120
...VKLTEV	539	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18125
...VKLTEV	539	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135530
...KDKRR	717	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KDKRR	717	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80867

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	9	TLQE.\|.EQLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	9	TLQE.\|.EQLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	390	DVLE.\|.EMVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	539	LTEV.\|.VPVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)