O43175: D-3-phosphoglycerate dehydrogenase

General Information

Protein names	- D-3-phosphoglycerate dehydrogenase - 3-PGDH - 1.1.1.95 {ECO:0000269\|PubMed:11751922} - 2-oxoglutarate reductase {ECO:0000305} - 1.1.1.399 {ECO:0000269\|PubMed:25406093} - Malate dehydrogenase {ECO:0000305} - 1.1.1.37 {ECO:0000269\|PubMed:25406093}
Gene names	PHGDH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43175

13 N-termini

11 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT
        70         80         90        100        110        120
ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ
       130        140        150        160        170        180
IPQATASMKD GKWERKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TIGYDPIISP
       190        200        210        220        230        240
EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV
       250        260        270        280        290        300
DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA
       310        320        330        340        350        360
VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP KGTIQVITQG
       370        380        390        400        410        420
TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA GLNVTTSHSP AAPGEQGFGE
       430        440        450        460        470        480
CLLAVALAGA PYQAVGLVQG TTPVLQGLNG AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT
       490        500        510        520        530
MIGLLAEAGV RLLSYQTSLV SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 11 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43175-2-unknown	MAFANL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43175-2-Acetylation	AFANLR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43175-2-Acetylation	AFANLR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O43175-2-Acetylation	AFANLR...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O43175-2-Acetylation	AFANLR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43175-33-unknown	KQNLSK...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10726
O43175-47-unknown	DCEGLI...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7018
O43175-63-unknown	VINAAE...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10727
O43175-76-unknown	AGTGVD...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9879
O43175-261-unknown	VFTEEP...	261		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10728
O43175-275-unknown	HENVIS...	275		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18225
O43175-276-unknown	ENVISC...	276		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18226
O43175-280-unknown	SCPHLG...	280		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5149
O43175-323-	SAFSPH...	323			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43175-406-unknown	TSHSPA...	406		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5150
O43175-437-unknown	LVQGTT...	437		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3267

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LQVVEK	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10726
...IAELQD	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7018
...KVTADV	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10727
...QVVGRA	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9879
...GAALDV	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10728
...RALVDH	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18225
...ALVDHE	275	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18226
...HENVIS	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5149
...GLNVTT	405	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5150
...YQAVGL	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3267
...FQFHF	533	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	32	VVEK.\|.KQNL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	46	ELQD.\|.DCEG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	62	TADV.\|.VINA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	75	VGRA.\|.AGTG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	260	ALDV.\|.VFTE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	274	LVDH.\|.HENV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	275	VDHE.\|.ENVI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	279	NVIS.\|.SCPH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	405	NVTT.\|.TSHS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	436	AVGL.\|.LVQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)