P30825: High affinity cationic amino acid transporter 1

General Information

Protein names	- High affinity cationic amino acid transporter 1 - CAT-1 {ECO:0000303\|PubMed:10485994} - CAT1 - Ecotropic retroviral leukemia receptor homolog - Ecotropic retrovirus receptor homolog - Solute carrier family 7 member 1 {ECO:0000312\|HGNC:HGNC:11057} - System Y+ basic amino acid transporter
Gene names	SLC7A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30825

2 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE
        70         80         90        100        110        120
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS
       130        140        150        160        170        180
YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT
       190        200        210        220        230        240
LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG
       250        260        270        280        290        300
KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA
       310        320        330        340        350        360
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR
       370        380        390        400        410        420
VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY
       430        440        450        460        470        480
SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI
       490        500        510        520        530        540
LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA
       550        560        570        580        590        600
VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY
       610        620
FGYGLWHSEE ASLDADQART PDGNLDQCK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30825-1-unknown	MGCKVL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30825-2-unknown	GCKVLL...	2		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19031

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LILSYI	121	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390092
...LDQCK	629	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LDQCK	629		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LDQCK	629		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	1	.\|.GCKV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)