Q14166: Tubulin--tyrosine ligase-like protein 12

General Information

Protein names	- Tubulin--tyrosine ligase-like protein 12
Gene names	TTLL12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14166

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG RLLHKLEHEV
        70         80         90        100        110        120
FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK VIVTRESGLQ AAHPNSIFLI
       130        140        150        160        170        180
DHAWTCRVEH ARQQLQQVPG LLHRMANLMG IEFHGELPST EAVALVLEEM WKFNQTYQLA
       190        200        210        220        230        240
HGTAEEKMPV WYIMDEFGSR IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR
       250        260        270        280        290        300
DFAYGETDPL IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP
       310        320        330        340        350        360
HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE RPGVLLNQFP
       370        380        390        400        410        420
CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF VSYFQQRERW GEDNHWICKP
       430        440        450        460        470        480
WNLARSLDTH VTKSLHSIIR HRESTPKVVS KYIESPVLFL REDVGKVKFD IRYIVLLRSV
       490        500        510        520        530        540
RPLRLFVYDV FWLRFSNRAF ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP
       550        560        570        580        590        600
EFPWTDVQAE IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ
       610        620        630        640
PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14166-1-unknown	MEAERG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14166-30-unknown	EFAALH...	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19507
Q14166-68-	GIMQVE...	68		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14166-137-unknown	QVPGLL...	137	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7828
Q14166-307-	VYTDVQ...	307		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14166-307-	VYTDVQ...	307		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14166-309-	TDVQQV...	309		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14166-516-	NYDPDV...	516		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14166-580-unknown	MYAVDL...	580	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000476297

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AQALAE	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19507
...RQQLQQ	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7828
...VTCLV	644	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	29	ALAE.\|.EFAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	136	QLQQ.\|.QVPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)