Q02878: 60S ribosomal protein L6

General Information

Protein names	- 60S ribosomal protein L6 - Large ribosomal subunit protein eL6 {ECO:0000303\|PubMed:24524803} - Neoplasm-related protein C140 - Tax-responsive enhancer element-binding protein 107 - TaxREB107
Gene names	RPL6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02878

14 N-termini

14 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS
        70         80         90        100        110        120
AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED
       130        140        150        160        170        180
VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV
       190        200        210        220        230        240
LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY
       250        260        270        280
EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 14 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q02878-2-	AGEKVE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q02878-2-	AGEKVE...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02878-2-	AGEKVE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02878-2-unknown	AGEKVE...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02878-2-unknown	AGEKVE...	2	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q02878-2-unknown	AGEKVE...	2		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02878-3-	GEKVEK...	3		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02878-86-	EKVLAT...	86		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02878-88-	VLATVT...	88		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q02878-88-	VLATVT...	88		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02878-88-	VLATVT...	88		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02878-88-	VLATVT...	88		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q02878-91-unknown	TVTKPV...	91	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17839
Q02878-92-unknown	VTKPVG...	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3955
Q02878-112-unknown	MPRYYP...	112	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448570
Q02878-115-	YYPTED...	115		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02878-115-	YYPTED...	115		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02878-115-	YYPTED...	115		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q02878-115-	YYPTED...	115		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q02878-115-	YYPTED...	115		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02878-115-unknown	YYPTED...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14365
Q02878-115-unknown	YYPTED...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10191
Q02878-124-unknown	KLLSHG...	124	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10192
Q02878-230-unknown	GEIFDT...	230	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17840
Q02878-234-unknown	DTEKEK...	234	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19327
Q02878-235-unknown	TEKEKY...	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19328
Q02878-235-unknown	TEKEKY...	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17841

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKVLAT	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17839
...KVLATV	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3955
...NGGTRV	105	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446859
...RKMPRY	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14365
...RKMPRY	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10191
...RYYPTE	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449486
...YPTEDV	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448067
...EDVPRK	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10192
...GRHRGK	159	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446883
...RHRGKR	160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476161
...SGLLLV	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448570
...PRHQEG	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17840
...EGEIFD	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19327
...GEIFDT	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19328
...GEIFDT	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17841
...HKLVF	288	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	90	VLAT.\|.TVTK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	91	LATV.\|.VTKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	114	MPRY.\|.YYPT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	114	MPRY.\|.YYPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	123	VPRK.\|.KLLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	229	HQEG.\|.GEIF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	233	EIFD.\|.DTEK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	234	IFDT.\|.TEKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	234	IFDT.\|.TEKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)