P30613: Pyruvate kinase PKLR

General Information

Protein names	- Pyruvate kinase PKLR - 2.7.1.40 - Pyruvate kinase 1 - Pyruvate kinase isozymes L/R - R-type/L-type pyruvate kinase - Red cell/liver pyruvate kinase
Gene names	PKLR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30613

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGGPAGYLR RASVAQLTQE LGTAFFQQQQ
        70         80         90        100        110        120
LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS VERLKEMIKA GMNIARLNFS
       130        140        150        160        170        180
HGSHEYHAES IANVREAVES FAGSPLSYRP VAIALDTKGP EIRTGILQGG PESEVELVKG
       190        200        210        220        230        240
SQVLVTVDPA FRTRGNANTV WVDYPNIVRV VPVGGRIYID DGLISLVVQK IGPEGLVTQV
       250        260        270        280        290        300
ENGGVLGSRK GVNLPGAQVD LPGLSEQDVR DLRFGVEHGV DIVFASFVRK ASDVAAVRAA
       310        320        330        340        350        360
LGPEGHGIKI ISKIENHEGV KRFDEILEVS DGIMVARGDL GIEIPAEKVF LAQKMMIGRC
       370        380        390        400        410        420
NLAGKPVVCA TQMLESMITK PRPTRAETSD VANAVLDGAD CIMLSGETAK GNFPVEAVKM
       430        440        450        460        470        480
QHAIAREAEA AVYHRQLFEE LRRAAPLSRD PTEVTAIGAV EAAFKCCAAA IIVLTTTGRS
       490        500        510        520        530        540
AQLLSRYRPR AAVIAVTRSA QAARQVHLCR GVFPLLYREP PEAIWADDVD RRVQFGIESG
       550        560        570
KLRGFLRVGD LVIVVTGWRP GSGYTNIMRV LSIS

Isoforms

- Isoform L-type of Pyruvate kinase PKLR

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30613-1-unknown	MSIQEN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30613-2-acetylation	SIQENI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30613-2-acetylation	SIQENI...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30613-150-acetylation	PVAIAL...	150	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30613-150-acetylation	PVAIAL...	150	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182632
P30613-338-unknown	GDLGIE...	338		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19029
P30613-338-unknown	GDLGIE...	338		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150051

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IMVARG	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19029
...IMVARG	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133443
...VLSIS	574	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VLSIS	574	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74843

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	337	VARG.\|.GDLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)