P30613: Pyruvate kinase PKLR
Protein names | - Pyruvate kinase PKLR - 2.7.1.40 - Pyruvate kinase 1 - Pyruvate kinase isozymes L/R - R-type/L-type pyruvate kinase - Red cell/liver pyruvate kinase |
---|---|
Gene names | PKLR |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P30613 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGGPAGYLR RASVAQLTQE LGTAFFQQQQ
70 80 90 100 110 120
LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS VERLKEMIKA GMNIARLNFS
130 140 150 160 170 180
HGSHEYHAES IANVREAVES FAGSPLSYRP VAIALDTKGP EIRTGILQGG PESEVELVKG
190 200 210 220 230 240
SQVLVTVDPA FRTRGNANTV WVDYPNIVRV VPVGGRIYID DGLISLVVQK IGPEGLVTQV
250 260 270 280 290 300
ENGGVLGSRK GVNLPGAQVD LPGLSEQDVR DLRFGVEHGV DIVFASFVRK ASDVAAVRAA
310 320 330 340 350 360
LGPEGHGIKI ISKIENHEGV KRFDEILEVS DGIMVARGDL GIEIPAEKVF LAQKMMIGRC
370 380 390 400 410 420
NLAGKPVVCA TQMLESMITK PRPTRAETSD VANAVLDGAD CIMLSGETAK GNFPVEAVKM
430 440 450 460 470 480
QHAIAREAEA AVYHRQLFEE LRRAAPLSRD PTEVTAIGAV EAAFKCCAAA IIVLTTTGRS
490 500 510 520 530 540
AQLLSRYRPR AAVIAVTRSA QAARQVHLCR GVFPLLYREP PEAIWADDVD RRVQFGIESG
550 560 570
KLRGFLRVGD LVIVVTGWRP GSGYTNIMRV LSIS
Isoforms
- Isoform L-type of Pyruvate kinase PKLRSequence View
10 20 30 40 50 60
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGGPAGYLR RASVAQLTQE LGTAFFQQQQ
70 80 90 100 110 120
LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS VERLKEMIKA GMNIARLNFS
130 140 150 160 170 180
HGSHEYHAES IANVREAVES FAGSPLSYRP VAIALDTKGP EIRTGILQGG PESEVELVKG
190 200 210 220 230 240
SQVLVTVDPA FRTRGNANTV WVDYPNIVRV VPVGGRIYID DGLISLVVQK IGPEGLVTQV
250 260 270 280 290 300
ENGGVLGSRK GVNLPGAQVD LPGLSEQDVR DLRFGVEHGV DIVFASFVRK ASDVAAVRAA
310 320 330 340 350 360
LGPEGHGIKI ISKIENHEGV KRFDEILEVS DGIMVARGDL GIEIPAEKVF LAQKMMIGRC
370 380 390 400 410 420
NLAGKPVVCA TQMLESMITK PRPTRAETSD VANAVLDGAD CIMLSGETAK GNFPVEAVKM
430 440 450 460 470 480
QHAIAREAEA AVYHRQLFEE LRRAAPLSRD PTEVTAIGAV EAAFKCCAAA IIVLTTTGRS
490 500 510 520 530 540
AQLLSRYRPR AAVIAVTRSA QAARQVHLCR GVFPLLYREP PEAIWADDVD RRVQFGIESG
550 560 570
KLRGFLRVGD LVIVVTGWRP GSGYTNIMRV LSIS
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P30613-1-unknown | MSIQEN... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P30613-2-acetylation | SIQENI... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P30613-2-acetylation | SIQENI... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P30613-150-acetylation | PVAIAL... | 150 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P30613-150-acetylation | PVAIAL... | 150 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182632 | ||
P30613-338-unknown | GDLGIE... | 338 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19029 | |||
P30613-338-unknown | GDLGIE... | 338 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150051 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IMVARG | 337 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19029 | |||
...IMVARG | 337 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133443 | |||
...VLSIS | 574 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VLSIS | 574 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt74843 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1B_HUMAN | 337 | VARG.|.GDLG | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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