P36578: 60S ribosomal protein L4

General Information

Protein names	- 60S ribosomal protein L4 - 60S ribosomal protein L1 - Large ribosomal subunit protein uL4 {ECO:0000303\|PubMed:24524803}
Gene names	RPL4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36578

29 N-termini

15 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH
        70         80         90        100        110        120
QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK
       130        140        150        160        170        180
RYAICSALAA SALPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI
       190        200        210        220        230        240
KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL
       250        260        270        280        290        300
APGGHVGRFC IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR
       310        320        330        340        350        360
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR VDKAAAAAAA
       370        380        390        400        410        420
LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK AAATKKPAPE KKPAEKKPTT

EEKKPAA

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

29 N-termini - 15 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P36578-2-unknown	MACARP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36578-2-Acetylation	ACARPL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36578-2-Acetylation	ACARPL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P36578-36-unknown	IVNFVH...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1219
P36578-36-unknown	IVNFVH...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11475
P36578-53-	AVSELA...	53			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-53-	AVSELA...	53			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P36578-53-	AVSELA...	53			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P36578-56-unknown	ELAGHQ...	56		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P36578-57-unknown	LAGHQT...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3785
P36578-57-	LAGHQT...	57			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-58-	AGHQTS...	58			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P36578-59-unknown	GHQTSA...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7448
P36578-59-unknown	GHQTSA...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5823
P36578-63-	SAESWG...	63			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-95-unknown	MCRGGR...	95		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000454281
P36578-101-	MFAPTK...	101			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-122-unknown	YAICSA...	122		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10062
P36578-127-unknown	ALAASA...	127		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19081
P36578-129-	AASALP...	129			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P36578-129-unknown	AASALP...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14100
P36578-141-	GHRIEE...	141			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-147-unknown	VPELPL...	147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17620
P36578-206-unknown	GPCIIY...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10063
P36578-215-unknown	NGIIKA...	215		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11476
P36578-320-unknown	KNLRIM...	320		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14101
P36578-321-unknown	NLRIML...	321		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14102
P36578-327-unknown	KLNPYA...	327		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14103
P36578-354-	AAAAAA...	354			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P36578-355-	AAAAAA...	355			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P36578-369-unknown	AAVAGK...	369			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P36578-369-	AAVAGK...	369			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P36578-406-	KPAPEK...	406			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P36578-412-	KPAEKK...	412			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIRPDI	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1219
...PIRPDI	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11475
...YAVSEL	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3785
...VSELAG	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7448
...VSELAG	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5823
...TTQKRY	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10062
...YAICSA	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19081
...ICSALA	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14100
...HRIEEV	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17620
...DIKKVY	183	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457268
...RIQRRG	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10063
...IYNEDN	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11476
...KKNPLK	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14101
...KNPLKN	320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14102
...LRIMLK	326	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14103
...KAAVAG	372	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457442
...KKPAA	427	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	35	RPDI.\|.IVNF	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	35	RPDI.\|.IVNF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATB_HUMAN	56	VSEL.\|.LAGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	58	ELAG.\|.GHQT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	58	ELAG.\|.GHQT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	121	QKRY.\|.YAIC	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1B_HUMAN	126	ICSA.\|.ALAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	128	SALA.\|.AASA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	146	IEEV.\|.VPEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	205	QRRG.\|.GPCI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	214	NEDN.\|.NGII	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	319	NPLK.\|.KNLR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	320	PLKN.\|.NLRI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	326	IMLK.\|.KLNP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)