P15374: Ubiquitin carboxyl-terminal hydrolase isozyme L3

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase isozyme L3 - UCH-L3 - 3.4.19.12 - Ubiquitin thioesterase L3
Gene names	UCHL3
Organism	Homo sapiens
Protease Family
Protease ID	C12.003
Chromosome location
UniProt ID	P15374

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE
        70         80         90        100        110        120
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK
       130        140        150        160        170        180
KFLEESVSMS PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL
       190        200        210        220        230
YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P15374-1-unknown	MEGQRW...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P15374-11-unknown	ANPEVT...	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18763
P15374-67-unknown	TEEEEK...	67	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398189

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...WLPLEA	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18763
...ALSAA	230	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ALSAA	230		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	10	PLEA.\|.ANPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)