P06396: Gelsolin

General Information

Protein names	- Gelsolin - AGEL - Actin-depolymerizing factor - ADF - Brevin
Gene names	GSN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06396

33 N-termini

14 C-termini

16 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Gelsolin - Isoform 3 of Gelsolin - Isoform 4 of Gelsolin

Sequence View

        10         20         30         40         50         60
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN SMVVEHPEFL
        70         80         90        100        110        120
KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT VQLRNGNLQY DLHYWLGNEC
       130        140        150        160        170        180
SQDESGAAAI FTVQLDDYLN GRAVQHREVQ GFESATFLGY FKSGLKYKKG GVASGFKHVV
       190        200        210        220        230        240
PNEVVVQRLF QVKGRRVVRA TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA
       250        260        270        280        290        300
TQVSKGIRDN ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL
       310        320        330        340        350        360
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA NTEERKAALK
       370        380        390        400        410        420
TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD QTDGLGLSYL SSHIANVERV
       430        440        450        460        470        480
PFDAATLHTS TAMAAQHGMD DDGTGQKQIW RIEGSNKVPV DPATYGQFYG GDSYIILYNY
       490        500        510        520        530        540
RHGGRQGQII YNWQGAQSTQ DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG
       550        560        570        580        590        600
GKPMIIYKGG TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS
       610        620        630        640        650        660
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA YRTSPRLKDK
       670        680        690        700        710        720
KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML LDTWDQVFVW VGKDSQEEEK
       730        740        750        760        770        780
TEALTSAKRY IETDPANRDR RTPITVVKQG FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL

AA         10         20         30         40         50         60
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN SMVVEHPEFL
        70         80         90        100        110        120
KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT VQLRNGNLQY DLHYWLGNEC
       130        140        150        160        170        180
SQDESGAAAI FTVQLDDYLN GRAVQHREVQ GFESATFLGY FKSGLKYKKG GVASGFKHVV
       190        200        210        220        230        240
PNEVVVQRLF QVKGRRVVRA TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA
       250        260        270        280        290        300
TQVSKGIRDN ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL
       310        320        330        340        350        360
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA NTEERKAALK
       370        380        390        400        410        420
TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD QTDGLGLSYL SSHIANVERV
       430        440        450        460        470        480
PFDAATLHTS TAMAAQHGMD DDGTGQKQIW RIEGSNKVPV DPATYGQFYG GDSYIILYNY
       490        500        510        520        530        540
RHGGRQGQII YNWQGAQSTQ DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG
       550        560        570        580        590        600
GKPMIIYKGG TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS
       610        620        630        640        650        660
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA YRTSPRLKDK
       670        680        690        700        710        720
KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML LDTWDQVFVW VGKDSQEEEK
       730        740        750        760        770        780
TEALTSAKRY IETDPANRDR RTPITVVKQG FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL

AA         10         20         30         40         50         60
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN SMVVEHPEFL
        70         80         90        100        110        120
KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT VQLRNGNLQY DLHYWLGNEC
       130        140        150        160        170        180
SQDESGAAAI FTVQLDDYLN GRAVQHREVQ GFESATFLGY FKSGLKYKKG GVASGFKHVV
       190        200        210        220        230        240
PNEVVVQRLF QVKGRRVVRA TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA
       250        260        270        280        290        300
TQVSKGIRDN ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL
       310        320        330        340        350        360
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA NTEERKAALK
       370        380        390        400        410        420
TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD QTDGLGLSYL SSHIANVERV
       430        440        450        460        470        480
PFDAATLHTS TAMAAQHGMD DDGTGQKQIW RIEGSNKVPV DPATYGQFYG GDSYIILYNY
       490        500        510        520        530        540
RHGGRQGQII YNWQGAQSTQ DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG
       550        560        570        580        590        600
GKPMIIYKGG TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS
       610        620        630        640        650        660
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA YRTSPRLKDK
       670        680        690        700        710        720
KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML LDTWDQVFVW VGKDSQEEEK
       730        740        750        760        770        780
TEALTSAKRY IETDPANRDR RTPITVVKQG FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL

AA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

33 N-termini - 14 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06396-28-unknown	ATASRG...	28	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06396-28-unknown	ATASRG...	28		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-29-unknown	TASRGA...	29		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-30-unknown	ASRGAS...	30		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-31-unknown	SRGASQ...	31		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-33-unknown	GASQAG...	33		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-34-unknown	ASQAGA...	34		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-35-unknown	SQAGAP...	35		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-51-unknown	SMVVEH...	51	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17133
P06396-51-unknown	SMVVEH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196143
P06396-51-unknown	SMVVEH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196144
P06396-52-unknown	MVVEHP...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75875
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000362929
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404226
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409358
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416586
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000340888
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000362914
P06396-52-unknown	MVVEHP...	52	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P06396-52-unknown	MVVEHP...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23805
P06396-52-unknown	MVVEHP...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101529
P06396-52-unknown	MVVEHP...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101530
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06396-52-	MVVEHP...	52		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06396-53-	VVEHPE...	53		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P06396-53-	VVEHPE...	53		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06396-53-	VVEHPE...	53		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06396-53-	VVEHPE...	53		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06396-53-	VVEHPE...	53		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06396-53-unknown	VVEHPE...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164318
P06396-53-unknown	VVEHPE...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164316
P06396-53-unknown	VVEHPE...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164317
P06396-178-unknown	HVVPNE...	178		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-178-unknown	HVVPNE...	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180424
P06396-178-unknown	HVVPNE...	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180422
P06396-178-unknown	HVVPNE...	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180423
P06396-270-unknown	MLQVLG...	270	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000362913
P06396-270-unknown	MLQVLG...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198617
P06396-270-unknown	MLQVLG...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198615
P06396-270-unknown	MLQVLG...	270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198616
P06396-275-unknown	GPKPAL...	275	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5406
P06396-275-unknown	GPKPAL...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147507
P06396-275-unknown	GPKPAL...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147791
P06396-275-unknown	GPKPAL...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147913
P06396-279-unknown	ALPAGT...	279		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-279-unknown	ALPAGT...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180428
P06396-279-unknown	ALPAGT...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180426
P06396-279-unknown	ALPAGT...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180427
P06396-280-unknown	LPAGTE...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18501
P06396-280-unknown	LPAGTE...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17134
P06396-280-unknown	LPAGTE...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147690
P06396-280-unknown	LPAGTE...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147961
P06396-280-unknown	LPAGTE...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148081
P06396-347-unknown	GKQANT...	347		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-347-unknown	GKQANT...	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180432
P06396-347-unknown	GKQANT...	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180430
P06396-347-unknown	GKQANT...	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180431
P06396-398-unknown	DPDQTD...	398	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18505
P06396-398-unknown	DPDQTD...	398	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17138
P06396-398-unknown	DPDQTD...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150888
P06396-398-unknown	DPDQTD...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151050
P06396-398-unknown	DPDQTD...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151106
P06396-403-unknown	DGLGLS...	403	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18509
P06396-403-unknown	DGLGLS...	403	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150981
P06396-403-unknown	DGLGLS...	403	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151162
P06396-403-unknown	DGLGLS...	403	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151249
P06396-404-	GLGLSY...	404		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P06396-404-	GLGLSY...	404		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06396-404-unknown	GLGLSY...	404	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1125
P06396-404-unknown	GLGLSY...	404	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2790
P06396-404-unknown	GLGLSY...	404		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-404-unknown	GLGLSY...	404	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151009
P06396-404-unknown	GLGLSY...	404	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151203
P06396-404-unknown	GLGLSY...	404	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151277
P06396-408-	SYLSSH...	408		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06396-408-unknown	SYLSSH...	408		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-408-unknown	SYLSSH...	408	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165255
P06396-408-unknown	SYLSSH...	408	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165253
P06396-408-unknown	SYLSSH...	408	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165254
P06396-411-unknown	SSHIAN...	411		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-411-unknown	SSHIAN...	411	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180437
P06396-411-unknown	SSHIAN...	411	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180435
P06396-411-unknown	SSHIAN...	411	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180436
P06396-412-unknown	SHIANV...	412		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-412-unknown	SHIANV...	412	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180441
P06396-412-unknown	SHIANV...	412	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180439
P06396-412-unknown	SHIANV...	412	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180440
P06396-417-unknown	VERVPF...	417	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23806
P06396-417-unknown	VERVPF...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151317
P06396-417-unknown	VERVPF...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151498
P06396-417-unknown	VERVPF...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151549
P06396-423-unknown	DAATLH...	423	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18513
P06396-423-unknown	DAATLH...	423	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17142
P06396-423-unknown	DAATLH...	423	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151443
P06396-423-unknown	DAATLH...	423	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151605
P06396-423-unknown	DAATLH...	423	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151696
P06396-434-unknown	AAQHGM...	434		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P06396-434-unknown	AAQHGM...	434	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180445
P06396-434-unknown	AAQHGM...	434	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180443
P06396-434-unknown	AAQHGM...	434	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180444
P06396-435-unknown	AQHGMD...	435	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18517
P06396-435-unknown	AQHGMD...	435	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17146
P06396-435-unknown	AQHGMD...	435	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151713
P06396-435-unknown	AQHGMD...	435	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151872
P06396-435-unknown	AQHGMD...	435	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151916
P06396-436-unknown	QHGMDD...	436	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23810
P06396-436-unknown	QHGMDD...	436	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151727
P06396-436-unknown	QHGMDD...	436	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151886
P06396-436-unknown	QHGMDD...	436	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151924
P06396-640-unknown	GFWEAL...	640	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165251
P06396-640-unknown	GFWEAL...	640	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165249
P06396-640-unknown	GFWEAL...	640	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165250
P06396-640-	GFWEAL...	640		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EARPNS	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17133
...ARPNSM	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23805
...GTEPEA	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410657
...MLQVLG	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5406
...MLQVLG	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130857
...MLQVLG	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131147
...MLQVLG	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131273
...GPKPAL	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18501
...GPKPAL	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17134
...GPKPAL	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131043
...GPKPAL	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131322
...GPKPAL	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131445
...AGTMSV	311	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404226
...FKNWRD	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18505
...FKNWRD	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17138
...FKNWRD	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134290
...FKNWRD	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134453
...FKNWRD	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134508
...DPDQTD	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18509
...DPDQTD	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134384
...DPDQTD	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134564
...DPDQTD	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134650
...PDQTDG	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1125
...PDQTDG	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2790
...PDQTDG	403	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134412
...PDQTDG	403	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134605
...PDQTDG	403	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134679
...SHIANV	416	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23806
...SHIANV	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134719
...SHIANV	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134903
...SHIANV	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134954
...ERVPFD	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18513
...ERVPFD	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17142
...ERVPFD	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134846
...ERVPFD	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135012
...ERVPFD	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135099
...STAMAA	434	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18517
...STAMAA	434	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17146
...STAMAA	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135117
...STAMAA	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135277
...STAMAA	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135324
...TAMAAQ	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23810
...TAMAAQ	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135131
...TAMAAQ	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135291
...TAMAAQ	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135332
...AELAA	782	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AELAA	782	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71493
...AELAA	782	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71495
...AELAA	782	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71494

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	50	RPNS.\|.SMVV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP3_HUMAN	51	PNSM.\|.MVVE	inferred from experiment	unknown	MEROPS	Lee ST	Park SM et al.:Characterization of plasma gels... (M10.005)	16421935,
CATL1_HUMAN	274	QVLG.\|.GPKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	279	KPAL.\|.LPAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	279	KPAL.\|.LPAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	397	NWRD.\|.DPDQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	397	NWRD.\|.DPDQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	402	DQTD.\|.DGLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP1_HUMAN	403	QTDG.\|.GLGL	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP7_HUMAN	403	QTDG.\|.GLGL	inferred from experiment	unknown	MEROPS	Williams LT	Kothakota S et al.:Caspase-3-generated fragment of... (C14.004)	9323209,
MMP3_HUMAN	416	IANV.\|.VERV	inferred from experiment	unknown	MEROPS	Lee ST	Park SM et al.:Characterization of plasma gels... (M10.005)	16421935,
MEP1B_HUMAN	422	VPFD.\|.DAAT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	422	VPFD.\|.DAAT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	434	AMAA.\|.AQHG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	434	AMAA.\|.AQHG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP3_HUMAN	435	MAAQ.\|.QHGM	inferred from experiment	unknown	MEROPS	Lee ST	Park SM et al.:Characterization of plasma gels... (M10.005)	16421935,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)