P14859: POU domain, class 2, transcription factor 1

General Information

Protein names	- POU domain, class 2, transcription factor 1 - NF-A1 - Octamer-binding protein 1 - Oct-1 - Octamer-binding transcription factor 1 - OTF-1
Gene names	POU2F1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14859

5 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of POU domain, class 2, transcription factor 1 - Isoform 3 of POU domain, class 2, transcription factor 1 - Isoform 6 of POU domain, class 2, transcription factor 1 - Isoform 4 of POU domain, class 2, transcription factor 1 - Isoform 5 of POU domain, class 2, transcription factor 1

Sequence View

        10         20         30         40         50         60
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS
        70         80         90        100        110        120
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
       130        140        150        160        170        180
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ
       190        200        210        220        230        240
QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ
       250        260        270        280        290        300
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
       310        320        330        340        350        360
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS
       370        380        390        400        410        420
SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK
       430        440        450        460        470        480
EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP
       490        500        510        520        530        540
VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA
       550        560        570        580        590        600
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP
       610        620        630        640        650        660
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV
       670        680        690        700        710        720
FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ
       730        740
NSLFTVASAS GAASTTTTAS KAQ         10         20         30         40         50         60
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS
        70         80         90        100        110        120
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
       130        140        150        160        170        180
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ
       190        200        210        220        230        240
QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ
       250        260        270        280        290        300
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
       310        320        330        340        350        360
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS
       370        380        390        400        410        420
SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK
       430        440        450        460        470        480
EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP
       490        500        510        520        530        540
VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA
       550        560        570        580        590        600
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP
       610        620        630        640        650        660
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV
       670        680        690        700        710        720
FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ
       730        740
NSLFTVASAS GAASTTTTAS KAQ         10         20         30         40         50         60
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS
        70         80         90        100        110        120
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
       130        140        150        160        170        180
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ
       190        200        210        220        230        240
QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ
       250        260        270        280        290        300
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
       310        320        330        340        350        360
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS
       370        380        390        400        410        420
SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK
       430        440        450        460        470        480
EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP
       490        500        510        520        530        540
VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA
       550        560        570        580        590        600
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP
       610        620        630        640        650        660
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV
       670        680        690        700        710        720
FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ
       730        740
NSLFTVASAS GAASTTTTAS KAQ         10         20         30         40         50         60
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS
        70         80         90        100        110        120
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
       130        140        150        160        170        180
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ
       190        200        210        220        230        240
QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ
       250        260        270        280        290        300
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
       310        320        330        340        350        360
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS
       370        380        390        400        410        420
SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK
       430        440        450        460        470        480
EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP
       490        500        510        520        530        540
VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA
       550        560        570        580        590        600
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP
       610        620        630        640        650        660
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV
       670        680        690        700        710        720
FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ
       730        740
NSLFTVASAS GAASTTTTAS KAQ         10         20         30         40         50         60
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS
        70         80         90        100        110        120
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ
       130        140        150        160        170        180
LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ
       190        200        210        220        230        240
QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ
       250        260        270        280        290        300
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI
       310        320        330        340        350        360
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS
       370        380        390        400        410        420
SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK
       430        440        450        460        470        480
EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP
       490        500        510        520        530        540
VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA
       550        560        570        580        590        600
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP
       610        620        630        640        650        660
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV
       670        680        690        700        710        720
FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ
       730        740
NSLFTVASAS GAASTTTTAS KAQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14859-1-unknown	MNNPSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14859-1-unknown	MNNPSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85708
P14859-1-unknown	MNNPSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105836
P14859-1-unknown	MNNPSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105834
P14859-1-unknown	MNNPSE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105835
P14859-63-	AAAQSL...	63		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14859-63-unknown	AAAQSL...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178363
P14859-63-unknown	AAAQSL...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178361
P14859-63-unknown	AAAQSL...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178364
P14859-63-unknown	AAAQSL...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178360
P14859-63-unknown	AAAQSL...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178362
P14859-93-unknown	VQAAIP...	93	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415993
P14859-93-unknown	VQAAIP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196836
P14859-93-unknown	VQAAIP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196834
P14859-93-unknown	VQAAIP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196837
P14859-93-unknown	VQAAIP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196835
P14859-280-unknown	EEPSDL...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18752
P14859-280-unknown	EEPSDL...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17359
P14859-280-unknown	EEPSDL...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148077
P14859-280-unknown	EEPSDL...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149287
P14859-280-unknown	EEPSDL...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149342
P14859-280-unknown	EEPSDL...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149633
P14859-280-unknown	EEPSDL...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149946

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DTPSLE	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18752
...DTPSLE	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17359
...DTPSLE	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131441
...DTPSLE	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132672
...DTPSLE	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132727
...DTPSLE	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133020
...DTPSLE	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133337
...ASKAQ	743	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ASKAQ	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81327
...ASKAQ	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81324
...ASKAQ	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81323
...ASKAQ	743	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81325

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	279	PSLE.\|.EEPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	279	PSLE.\|.EEPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)