P08727: Keratin, type I cytoskeletal 19

General Information

Protein names	- Keratin, type I cytoskeletal 19 - Cytokeratin-19 - CK-19 - Keratin-19 - K19
Gene names	KRT19
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08727

7 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA RFVSSSSSGA
        70         80         90        100        110        120
YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA LEAANGELEV KIRDWYQKQG
       130        140        150        160        170        180
PGPSRDYSHY YTTIQDLRDK ILGATIENSR IVLQIDNARL AADDFRTKFE TEQALRMSVE
       190        200        210        220        230        240
ADINGLRRVL DELTLARTDL EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA
       250        260        270        280        290        300
PGTDLAKILS DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR
       310        320        330        340        350        360
RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG DVRADSERQN
       370        380        390        400
QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08727-1-unknown	MTSYSY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08727-2-acetylation	TSYSYR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P08727-73-unknown	DGLLAG...	73		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18606
P08727-114-unknown	DWYQKQ...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17234
P08727-114-unknown	DWYQKQ...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18607
P08727-177-unknown	MSVEAD...	177		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466625
P08727-239-unknown	SAPGTD...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11135
P08727-281-unknown	EVAGHT...	281		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18608

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VLTASD	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18606
...EVKIRD	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17234
...EVKIRD	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18607
...STLRGQ	227	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408759
...SVEVDS	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11135
...EELNRE	280	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18608
...RADSER	357	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466625
...ASKVL	400	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	72	TASD.\|.DGLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	113	KIRD.\|.DWYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	113	KIRD.\|.DWYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	238	EVDS.\|.SAPG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	280	LNRE.\|.EVAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)