Q9UNZ2: NSFL1 cofactor p47

General Information

Protein names	- NSFL1 cofactor p47 - UBX domain-containing protein 2C - p97 cofactor p47
Gene names	NSFL1C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UNZ2

15 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of NSFL1 cofactor p47 - Isoform 3 of NSFL1 cofactor p47 - Isoform 4 of NSFL1 cofactor p47

Sequence View

        10         20         30         40         50         60
MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS
        70         80         90        100        110        120
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD
       130        140        150        160        170        180
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG EKRQHSSQDV
       190        200        210        220        230        240
HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD
       250        260        270        280        290        300
EDFVKPKGAF KAFTGEGQKL GSTAPQVLST SSPAQQAENE AKASSSILID ESEPTTNIQI
       310        320        330        340        350        360
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFILM TTFPNKELAD ESQTLKEANL
       370
LNAVIVQRLT         10         20         30         40         50         60
MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS
        70         80         90        100        110        120
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD
       130        140        150        160        170        180
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG EKRQHSSQDV
       190        200        210        220        230        240
HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD
       250        260        270        280        290        300
EDFVKPKGAF KAFTGEGQKL GSTAPQVLST SSPAQQAENE AKASSSILID ESEPTTNIQI
       310        320        330        340        350        360
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFILM TTFPNKELAD ESQTLKEANL
       370
LNAVIVQRLT         10         20         30         40         50         60
MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS
        70         80         90        100        110        120
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD
       130        140        150        160        170        180
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG EKRQHSSQDV
       190        200        210        220        230        240
HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD
       250        260        270        280        290        300
EDFVKPKGAF KAFTGEGQKL GSTAPQVLST SSPAQQAENE AKASSSILID ESEPTTNIQI
       310        320        330        340        350        360
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFILM TTFPNKELAD ESQTLKEANL
       370
LNAVIVQRLT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UNZ2-1-unknown	MAAERQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UNZ2-1-unknown	MAAERQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83348
Q9UNZ2-1-unknown	MAAERQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83349
Q9UNZ2-11-unknown	EFVAVT...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183259
Q9UNZ2-11-unknown	EFVAVT...	11		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183260
Q9UNZ2-11-	EFVAVT...	11			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9UNZ2-78-unknown	LIHDQD...	78		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175430
Q9UNZ2-78-	LIHDQD...	78			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UNZ2-78-	LIHDQD...	78			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UNZ2-82-acetylation	QDEDEE...	82	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9UNZ2-82-acetylation	QDEDEE...	82	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183274
Q9UNZ2-121-unknown	DLFKGA...	121		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19862
Q9UNZ2-121-unknown	DLFKGA...	121		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18171
Q9UNZ2-121-unknown	DLFKGA...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143527
Q9UNZ2-121-unknown	DLFKGA...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143620
Q9UNZ2-159-	AAPEEE...	159			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UNZ2-159-	AAPEEE...	159			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UNZ2-159-	AAPEEE...	159			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNZ2-159-unknown	AAPEEE...	159		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18174
Q9UNZ2-159-unknown	AAPEEE...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139041
Q9UNZ2-159-unknown	AAPEEE...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145168
Q9UNZ2-198-acetylation	LRSYQD...	198	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9UNZ2-198-acetylation	LRSYQD...	198	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183262
Q9UNZ2-198-acetylation	LRSYQD...	198	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183264
Q9UNZ2-198-acetylation	LRSYQD...	198	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183263
Q9UNZ2-200-unknown	SYQDPS...	200		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183266
Q9UNZ2-200-unknown	SYQDPS...	200		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183268
Q9UNZ2-200-unknown	SYQDPS...	200		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183267
Q9UNZ2-200-	SYQDPS...	200			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9UNZ2-225-acetylation	LAHGGQ...	225	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9UNZ2-225-acetylation	LAHGGQ...	225	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183270
Q9UNZ2-225-acetylation	LAHGGQ...	225	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183272
Q9UNZ2-225-acetylation	LAHGGQ...	225	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183271
Q9UNZ2-248-unknown	GAFKAF...	248		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164772
Q9UNZ2-248-unknown	GAFKAF...	248		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164774
Q9UNZ2-248-unknown	GAFKAF...	248		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164773
Q9UNZ2-248-	GAFKAF...	248			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UNZ2-248-	GAFKAF...	248			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NELVDD	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19862
...NELVDD	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18171
...NELVDD	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126767
...NELVDD	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126862
...GYRLGA	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18174
...GYRLGA	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122112
...GYRLGA	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128456
...VQRLT	370	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VQRLT	370	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78968
...VQRLT	370	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78966
...VQRLT	370	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78967

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	120	LVDD.\|.DLFK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	120	LVDD.\|.DLFK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	158	RLGA.\|.AAPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)