P46013: Proliferation marker protein Ki-67 {ECO:0000305}

General Information

Protein names	- Proliferation marker protein Ki-67 {ECO:0000305} - Antigen identified by monoclonal antibody Ki-67 {ECO:0000303\|PubMed:8227122} - Antigen KI-67 {ECO:0000305} - Antigen Ki67 {ECO:0000305}
Gene names	MKI67
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46013

19 N-termini

9 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Antigen KI-67 - Isoform Short of Proliferation marker protein Ki-67

Sequence View

        10         20         30         40         50         60
MWPTRRLVTI KRSGVDGPHF PLSLSTCLFG RGIECDIRIQ LPVVSKQHCK IEIHEQEAIL
        70         80         90        100        110        120
HNFSSTNPTQ VNGSVIDEPV RLKHGDVITI IDRSFRYENE SLQNGRKSTE FPRKIREQEP
       130        140        150        160        170        180
ARRVSRSSFS SDPDEKAQDS KAYSKITEGK VSGNPQVHIK NVKEDSTADD SKDSVAQGTT
       190        200        210        220        230        240
NVHSSEHAGR NGRNAADPIS GDFKEISSVK LVSRYGELKS VPTTQCLDNS KKNESPFWKL
       250        260        270        280        290        300
YESVKKELDV KSQKENVLQY CRKSGLQTDY ATEKESADGL QGETQLLVSR KSRPKSGGSG
       310        320        330        340        350        360
HAVAEPASPE QELDQNKGKG RDVESVQTPS KAVGASFPLY EPAKMKTPVQ YSQQQNSPQK
       370        380        390        400        410        420
HKNKDLYTTG RRESVNLGKS EGFKAGDKTL TPRKLSTRNR TPAKVEDAAD SATKPENLSS
       430        440        450        460        470        480
KTRGSIPTDV EVLPTETEIH NEPFLTLWLT QVERKIQKDS LSKPEKLGTT AGQMCSGLPG
       490        500        510        520        530        540
LSSVDINNFG DSINESEGIP LKRRRVSFGG HLRPELFDEN LPPNTPLKRG EAPTKRKSLV
       550        560        570        580        590        600
MHTPPVLKKI IKEQPQPSGK QESGSEIHVE VKAQSLVISP PAPSPRKTPV ASDQRRRSCK
       610        620        630        640        650        660
TAPASSSKSQ TEVPKRGGRK SGNLPSKRVS ISRSQHDILQ MICSKRRSGA SEANLIVAKS
       670        680        690        700        710        720
WADVVKLGAK QTQTKVIKHG PQRSMNKRQR RPATPKKPVG EVHSQFSTGH ANSPCTIIIG
       730        740        750        760        770        780
KAHTEKVHVP ARPYRVLNNF ISNQKMDFKE DLSGIAEMFK TPVKEQPQLT STCHIAISNS
       790        800        810        820        830        840
ENLLGKQFQG TDSGEEPLLP TSESFGGNVF FSAQNAAKQP SDKCSASPPL RRQCIRENGN
       850        860        870        880        890        900
VAKTPRNTYK MTSLETKTSD TETEPSKTVS TANRSGRSTE FRNIQKLPVE SKSEETNTEI
       910        920        930        940        950        960
VECILKRGQK ATLLQQRREG EMKEIERPFE TYKENIELKE NDEKMKAMKR SRTWGQKCAP
       970        980        990       1000       1010       1020
MSDLTDLKSL PDTELMKDTA RGQNLLQTQD HAKAPKSEKG KITKMPCQSL QPEPINTPTH
      1030       1040       1050       1060       1070       1080
TKQQLKASLG KVGVKEELLA VGKFTRTSGE TTHTHREPAG DGKSIRTFKE SPKQILDPAA
      1090       1100       1110       1120       1130       1140
RVTGMKKWPR TPKEEAQSLE DLAGFKELFQ TPGPSEESMT DEKTTKIACK SPPPESVDTP
      1150       1160       1170       1180       1190       1200
TSTKQWPKRS LRKADVEEEF LALRKLTPSA GKAMLTPKPA GGDEKDIKAF MGTPVQKLDL
      1210       1220       1230       1240       1250       1260
AGTLPGSKRQ LQTPKEKAQA LEDLAGFKEL FQTPGHTEEL VAAGKTTKIP CDSPQSDPVD
      1270       1280       1290       1300       1310       1320
TPTSTKQRPK RSIRKADVEG ELLACRNLMP SAGKAMHTPK PSVGEEKDII IFVGTPVQKL
      1330       1340       1350       1360       1370       1380
DLTENLTGSK RRPQTPKEEA QALEDLTGFK ELFQTPGHTE EAVAAGKTTK MPCESSPPES
      1390       1400       1410       1420       1430       1440
ADTPTSTRRQ PKTPLEKRDV QKELSALKKL TQTSGETTHT DKVPGGEDKS INAFRETAKQ
      1450       1460       1470       1480       1490       1500
KLDPAASVTG SKRHPKTKEK AQPLEDLAGL KELFQTPVCT DKPTTHEKTT KIACRSQPDP
      1510       1520       1530       1540       1550       1560
VDTPTSSKPQ SKRSLRKVDV EEEFFALRKR TPSAGKAMHT PKPAVSGEKN IYAFMGTPVQ
      1570       1580       1590       1600       1610       1620
KLDLTENLTG SKRRLQTPKE KAQALEDLAG FKELFQTRGH TEESMTNDKT AKVACKSSQP
      1630       1640       1650       1660       1670       1680
DPDKNPASSK RRLKTSLGKV GVKEELLAVG KLTQTSGETT HTHTEPTGDG KSMKAFMESP
      1690       1700       1710       1720       1730       1740
KQILDSAASL TGSKRQLRTP KGKSEVPEDL AGFIELFQTP SHTKESMTNE KTTKVSYRAS
      1750       1760       1770       1780       1790       1800
QPDLVDTPTS SKPQPKRSLR KADTEEEFLA FRKQTPSAGK AMHTPKPAVG EEKDINTFLG
      1810       1820       1830       1840       1850       1860
TPVQKLDQPG NLPGSNRRLQ TRKEKAQALE ELTGFRELFQ TPCTDNPTTD EKTTKKILCK
      1870       1880       1890       1900       1910       1920
SPQSDPADTP TNTKQRPKRS LKKADVEEEF LAFRKLTPSA GKAMHTPKAA VGEEKDINTF
      1930       1940       1950       1960       1970       1980
VGTPVEKLDL LGNLPGSKRR PQTPKEKAKA LEDLAGFKEL FQTPGHTEES MTDDKITEVS
      1990       2000       2010       2020       2030       2040
CKSPQPDPVK TPTSSKQRLK ISLGKVGVKE EVLPVGKLTQ TSGKTTQTHR ETAGDGKSIK
      2050       2060       2070       2080       2090       2100
AFKESAKQML DPANYGTGME RWPRTPKEEA QSLEDLAGFK ELFQTPDHTE ESTTDDKTTK
      2110       2120       2130       2140       2150       2160
IACKSPPPES MDTPTSTRRR PKTPLGKRDI VEELSALKQL TQTTHTDKVP GDEDKGINVF
      2170       2180       2190       2200       2210       2220
RETAKQKLDP AASVTGSKRQ PRTPKGKAQP LEDLAGLKEL FQTPICTDKP TTHEKTTKIA
      2230       2240       2250       2260       2270       2280
CRSPQPDPVG TPTIFKPQSK RSLRKADVEE ESLALRKRTP SVGKAMDTPK PAGGDEKDMK
      2290       2300       2310       2320       2330       2340
AFMGTPVQKL DLPGNLPGSK RWPQTPKEKA QALEDLAGFK ELFQTPGTDK PTTDEKTTKI
      2350       2360       2370       2380       2390       2400
ACKSPQPDPV DTPASTKQRP KRNLRKADVE EEFLALRKRT PSAGKAMDTP KPAVSDEKNI
      2410       2420       2430       2440       2450       2460
NTFVETPVQK LDLLGNLPGS KRQPQTPKEK AEALEDLVGF KELFQTPGHT EESMTDDKIT
      2470       2480       2490       2500       2510       2520
EVSCKSPQPE SFKTSRSSKQ RLKIPLVKVD MKEEPLAVSK LTRTSGETTQ THTEPTGDSK
      2530       2540       2550       2560       2570       2580
SIKAFKESPK QILDPAASVT GSRRQLRTRK EKARALEDLV DFKELFSAPG HTEESMTIDK
      2590       2600       2610       2620       2630       2640
NTKIPCKSPP PELTDTATST KRCPKTRPRK EVKEELSAVE RLTQTSGQST HTHKEPASGD
      2650       2660       2670       2680       2690       2700
EGIKVLKQRA KKKPNPVEEE PSRRRPRAPK EKAQPLEDLA GFTELSETSG HTQESLTAGK
      2710       2720       2730       2740       2750       2760
ATKIPCESPP LEVVDTTAST KRHLRTRVQK VQVKEEPSAV KFTQTSGETT DADKEPAGED
      2770       2780       2790       2800       2810       2820
KGIKALKESA KQTPAPAASV TGSRRRPRAP RESAQAIEDL AGFKDPAAGH TEESMTDDKT
      2830       2840       2850       2860       2870       2880
TKIPCKSSPE LEDTATSSKR RPRTRAQKVE VKEELLAVGK LTQTSGETTH TDKEPVGEGK
      2890       2900       2910       2920       2930       2940
GTKAFKQPAK RKLDAEDVIG SRRQPRAPKE KAQPLEDLAS FQELSQTPGH TEELANGAAD
      2950       2960       2970       2980       2990       3000
SFTSAPKQTP DSGKPLKISR RVLRAPKVEP VGDVVSTRDP VKSQSKSNTS LPPLPFKRGG
      3010       3020       3030       3040       3050       3060
GKDGSVTGTK RLRCMPAPEE IVEELPASKK QRVAPRARGK SSEPVVIMKR SLRTSAKRIE
      3070       3080       3090       3100       3110       3120
PAEELNSNDM KTNKEEHKLQ DSVPENKGIS LRSRRQNKTE AEQQITEVFV LAERIEINRN
      3130       3140       3150       3160       3170       3180
EKKPMKTSPE MDIQNPDDGA RKPIPRDKVT ENKRCLRSAR QNESSQPKVA EESGGQKSAK
      3190       3200       3210       3220       3230       3240
VLMQNQKGKG EAGNSDSMCL RSRKTKSQPA ASTLESKSVQ RVTRSVKRCA ENPKKAEDNV
      3250
CVKKIRTRSH RDSEDI         10         20         30         40         50         60
MWPTRRLVTI KRSGVDGPHF PLSLSTCLFG RGIECDIRIQ LPVVSKQHCK IEIHEQEAIL
        70         80         90        100        110        120
HNFSSTNPTQ VNGSVIDEPV RLKHGDVITI IDRSFRYENE SLQNGRKSTE FPRKIREQEP
       130        140        150        160        170        180
ARRVSRSSFS SDPDEKAQDS KAYSKITEGK VSGNPQVHIK NVKEDSTADD SKDSVAQGTT
       190        200        210        220        230        240
NVHSSEHAGR NGRNAADPIS GDFKEISSVK LVSRYGELKS VPTTQCLDNS KKNESPFWKL
       250        260        270        280        290        300
YESVKKELDV KSQKENVLQY CRKSGLQTDY ATEKESADGL QGETQLLVSR KSRPKSGGSG
       310        320        330        340        350        360
HAVAEPASPE QELDQNKGKG RDVESVQTPS KAVGASFPLY EPAKMKTPVQ YSQQQNSPQK
       370        380        390        400        410        420
HKNKDLYTTG RRESVNLGKS EGFKAGDKTL TPRKLSTRNR TPAKVEDAAD SATKPENLSS
       430        440        450        460        470        480
KTRGSIPTDV EVLPTETEIH NEPFLTLWLT QVERKIQKDS LSKPEKLGTT AGQMCSGLPG
       490        500        510        520        530        540
LSSVDINNFG DSINESEGIP LKRRRVSFGG HLRPELFDEN LPPNTPLKRG EAPTKRKSLV
       550        560        570        580        590        600
MHTPPVLKKI IKEQPQPSGK QESGSEIHVE VKAQSLVISP PAPSPRKTPV ASDQRRRSCK
       610        620        630        640        650        660
TAPASSSKSQ TEVPKRGGRK SGNLPSKRVS ISRSQHDILQ MICSKRRSGA SEANLIVAKS
       670        680        690        700        710        720
WADVVKLGAK QTQTKVIKHG PQRSMNKRQR RPATPKKPVG EVHSQFSTGH ANSPCTIIIG
       730        740        750        760        770        780
KAHTEKVHVP ARPYRVLNNF ISNQKMDFKE DLSGIAEMFK TPVKEQPQLT STCHIAISNS
       790        800        810        820        830        840
ENLLGKQFQG TDSGEEPLLP TSESFGGNVF FSAQNAAKQP SDKCSASPPL RRQCIRENGN
       850        860        870        880        890        900
VAKTPRNTYK MTSLETKTSD TETEPSKTVS TANRSGRSTE FRNIQKLPVE SKSEETNTEI
       910        920        930        940        950        960
VECILKRGQK ATLLQQRREG EMKEIERPFE TYKENIELKE NDEKMKAMKR SRTWGQKCAP
       970        980        990       1000       1010       1020
MSDLTDLKSL PDTELMKDTA RGQNLLQTQD HAKAPKSEKG KITKMPCQSL QPEPINTPTH
      1030       1040       1050       1060       1070       1080
TKQQLKASLG KVGVKEELLA VGKFTRTSGE TTHTHREPAG DGKSIRTFKE SPKQILDPAA
      1090       1100       1110       1120       1130       1140
RVTGMKKWPR TPKEEAQSLE DLAGFKELFQ TPGPSEESMT DEKTTKIACK SPPPESVDTP
      1150       1160       1170       1180       1190       1200
TSTKQWPKRS LRKADVEEEF LALRKLTPSA GKAMLTPKPA GGDEKDIKAF MGTPVQKLDL
      1210       1220       1230       1240       1250       1260
AGTLPGSKRQ LQTPKEKAQA LEDLAGFKEL FQTPGHTEEL VAAGKTTKIP CDSPQSDPVD
      1270       1280       1290       1300       1310       1320
TPTSTKQRPK RSIRKADVEG ELLACRNLMP SAGKAMHTPK PSVGEEKDII IFVGTPVQKL
      1330       1340       1350       1360       1370       1380
DLTENLTGSK RRPQTPKEEA QALEDLTGFK ELFQTPGHTE EAVAAGKTTK MPCESSPPES
      1390       1400       1410       1420       1430       1440
ADTPTSTRRQ PKTPLEKRDV QKELSALKKL TQTSGETTHT DKVPGGEDKS INAFRETAKQ
      1450       1460       1470       1480       1490       1500
KLDPAASVTG SKRHPKTKEK AQPLEDLAGL KELFQTPVCT DKPTTHEKTT KIACRSQPDP
      1510       1520       1530       1540       1550       1560
VDTPTSSKPQ SKRSLRKVDV EEEFFALRKR TPSAGKAMHT PKPAVSGEKN IYAFMGTPVQ
      1570       1580       1590       1600       1610       1620
KLDLTENLTG SKRRLQTPKE KAQALEDLAG FKELFQTRGH TEESMTNDKT AKVACKSSQP
      1630       1640       1650       1660       1670       1680
DPDKNPASSK RRLKTSLGKV GVKEELLAVG KLTQTSGETT HTHTEPTGDG KSMKAFMESP
      1690       1700       1710       1720       1730       1740
KQILDSAASL TGSKRQLRTP KGKSEVPEDL AGFIELFQTP SHTKESMTNE KTTKVSYRAS
      1750       1760       1770       1780       1790       1800
QPDLVDTPTS SKPQPKRSLR KADTEEEFLA FRKQTPSAGK AMHTPKPAVG EEKDINTFLG
      1810       1820       1830       1840       1850       1860
TPVQKLDQPG NLPGSNRRLQ TRKEKAQALE ELTGFRELFQ TPCTDNPTTD EKTTKKILCK
      1870       1880       1890       1900       1910       1920
SPQSDPADTP TNTKQRPKRS LKKADVEEEF LAFRKLTPSA GKAMHTPKAA VGEEKDINTF
      1930       1940       1950       1960       1970       1980
VGTPVEKLDL LGNLPGSKRR PQTPKEKAKA LEDLAGFKEL FQTPGHTEES MTDDKITEVS
      1990       2000       2010       2020       2030       2040
CKSPQPDPVK TPTSSKQRLK ISLGKVGVKE EVLPVGKLTQ TSGKTTQTHR ETAGDGKSIK
      2050       2060       2070       2080       2090       2100
AFKESAKQML DPANYGTGME RWPRTPKEEA QSLEDLAGFK ELFQTPDHTE ESTTDDKTTK
      2110       2120       2130       2140       2150       2160
IACKSPPPES MDTPTSTRRR PKTPLGKRDI VEELSALKQL TQTTHTDKVP GDEDKGINVF
      2170       2180       2190       2200       2210       2220
RETAKQKLDP AASVTGSKRQ PRTPKGKAQP LEDLAGLKEL FQTPICTDKP TTHEKTTKIA
      2230       2240       2250       2260       2270       2280
CRSPQPDPVG TPTIFKPQSK RSLRKADVEE ESLALRKRTP SVGKAMDTPK PAGGDEKDMK
      2290       2300       2310       2320       2330       2340
AFMGTPVQKL DLPGNLPGSK RWPQTPKEKA QALEDLAGFK ELFQTPGTDK PTTDEKTTKI
      2350       2360       2370       2380       2390       2400
ACKSPQPDPV DTPASTKQRP KRNLRKADVE EEFLALRKRT PSAGKAMDTP KPAVSDEKNI
      2410       2420       2430       2440       2450       2460
NTFVETPVQK LDLLGNLPGS KRQPQTPKEK AEALEDLVGF KELFQTPGHT EESMTDDKIT
      2470       2480       2490       2500       2510       2520
EVSCKSPQPE SFKTSRSSKQ RLKIPLVKVD MKEEPLAVSK LTRTSGETTQ THTEPTGDSK
      2530       2540       2550       2560       2570       2580
SIKAFKESPK QILDPAASVT GSRRQLRTRK EKARALEDLV DFKELFSAPG HTEESMTIDK
      2590       2600       2610       2620       2630       2640
NTKIPCKSPP PELTDTATST KRCPKTRPRK EVKEELSAVE RLTQTSGQST HTHKEPASGD
      2650       2660       2670       2680       2690       2700
EGIKVLKQRA KKKPNPVEEE PSRRRPRAPK EKAQPLEDLA GFTELSETSG HTQESLTAGK
      2710       2720       2730       2740       2750       2760
ATKIPCESPP LEVVDTTAST KRHLRTRVQK VQVKEEPSAV KFTQTSGETT DADKEPAGED
      2770       2780       2790       2800       2810       2820
KGIKALKESA KQTPAPAASV TGSRRRPRAP RESAQAIEDL AGFKDPAAGH TEESMTDDKT
      2830       2840       2850       2860       2870       2880
TKIPCKSSPE LEDTATSSKR RPRTRAQKVE VKEELLAVGK LTQTSGETTH TDKEPVGEGK
      2890       2900       2910       2920       2930       2940
GTKAFKQPAK RKLDAEDVIG SRRQPRAPKE KAQPLEDLAS FQELSQTPGH TEELANGAAD
      2950       2960       2970       2980       2990       3000
SFTSAPKQTP DSGKPLKISR RVLRAPKVEP VGDVVSTRDP VKSQSKSNTS LPPLPFKRGG
      3010       3020       3030       3040       3050       3060
GKDGSVTGTK RLRCMPAPEE IVEELPASKK QRVAPRARGK SSEPVVIMKR SLRTSAKRIE
      3070       3080       3090       3100       3110       3120
PAEELNSNDM KTNKEEHKLQ DSVPENKGIS LRSRRQNKTE AEQQITEVFV LAERIEINRN
      3130       3140       3150       3160       3170       3180
EKKPMKTSPE MDIQNPDDGA RKPIPRDKVT ENKRCLRSAR QNESSQPKVA EESGGQKSAK
      3190       3200       3210       3220       3230       3240
VLMQNQKGKG EAGNSDSMCL RSRKTKSQPA ASTLESKSVQ RVTRSVKRCA ENPKKAEDNV
      3250
CVKKIRTRSH RDSEDI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

19 N-termini - 9 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46013-1-unknown	MWPTRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46013-1-unknown	MWPTRR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78954
P46013-174-	SVAQGT...	174		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P46013-174-	SVAQGT...	174		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46013-174-	SVAQGT...	174		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P46013-174-	SVAQGT...	174		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P46013-279-	GLQGET...	279		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46013-411-	SATKPE...	411		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46013-411-	SATKPE...	411		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46013-411-	SATKPE...	411		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P46013-411-	SATKPE...	411		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P46013-492-	SINESE...	492		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P46013-969-unknown	SLPDTE...	969	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167118
P46013-969-	SLPDTE...	969		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46013-1176-unknown	TPKPAG...	1176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17655
P46013-1176-unknown	TPKPAG...	1176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156560
P46013-1189-	AFMGTP...	1189		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P46013-1189-unknown	AFMGTP...	1189		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46013-1189-unknown	AFMGTP...	1189	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161738
P46013-1374-unknown	ESSPPE...	1374	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14133
P46013-1374-unknown	ESSPPE...	1374	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157193
P46013-1482-unknown	KPTTHE...	1482	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11523
P46013-1482-unknown	KPTTHE...	1482	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157451
P46013-1739-unknown	ASQPDL...	1739	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10084
P46013-1739-unknown	ASQPDL...	1739	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157999
P46013-1747-unknown	TPTSSK...	1747	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19113
P46013-1747-unknown	TPTSSK...	1747	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5883
P46013-1747-unknown	TPTSSK...	1747	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158008
P46013-2085-unknown	TPDHTE...	2085	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5885
P46013-2085-unknown	TPDHTE...	2085	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158458
P46013-2148-	KVPGDE...	2148		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P46013-2148-	KVPGDE...	2148		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P46013-2148-unknown	KVPGDE...	2148		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46013-2148-unknown	KVPGDE...	2148	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161740
P46013-2152-unknown	DEDKGI...	2152	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19115
P46013-2152-unknown	DEDKGI...	2152	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17657
P46013-2152-unknown	DEDKGI...	2152	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158530
P46013-2491-unknown	MKEEPL...	2491	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11525
P46013-2491-unknown	MKEEPL...	2491	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158942

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKAMLT	1175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17655
...GKAMLT	1175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140044
...TKMPCE	1373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14133
...TKMPCE	1373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140694
...PVCTDK	1481	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11523
...PVCTDK	1481	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140949
...KVSYRA	1738	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10084
...KVSYRA	1738	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141494
...PDLVDT	1746	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19113
...PDLVDT	1746	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5883
...PDLVDT	1746	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141503
...KELFQT	2084	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5885
...DKVPGD	2151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19115
...DKVPGD	2151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17657
...DKVPGD	2151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142034
...LVKVDM	2490	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11525
...LVKVDM	2490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142446
...DSEDI	3256	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSEDI	3256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74572

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	1175	AMLT.\|.TPKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	1373	MPCE.\|.ESSP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	1481	CTDK.\|.KPTT	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
GRAA_HUMAN	1738	SYRA.\|.ASQP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1B_HUMAN	1746	LVDT.\|.TPTS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	1746	LVDT.\|.TPTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	2084	LFQT.\|.TPDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	2151	VPGD.\|.DEDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	2151	VPGD.\|.DEDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	2490	KVDM.\|.MKEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)