Q14204: Cytoplasmic dynein 1 heavy chain 1
Protein names | - Cytoplasmic dynein 1 heavy chain 1 - Cytoplasmic dynein heavy chain 1 - Dynein heavy chain, cytosolic |
---|---|
Gene names | DYNC1H1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q14204 |
10
N-termini
8
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSEPGGGGGE DGSAGLEVSA VQNVADVSVL QKHLRKLVPL LLEDGGEAPA ALEAALEEKS
70 80 90 100 110 120
ALEQMRKFLS DPQVHTVLVE RSTLKEDVGD EGEEEKEFIS YNINIDIHYG VKSNSLAFIK
130 140 150 160 170 180
RTPVIDADKP VSSQLRVLTL SEDSPYETLH SFISNAVAPF FKSYIRESGK ADRDGDKMAP
190 200 210 220 230 240
SVEKKIAELE MGLLHLQQNI EIPEISLPIH PMITNVAKQC YERGEKPKVT DFGDKVEDPT
250 260 270 280 290 300
FLNQLQSGVN RWIREIQKVT KLDRDPASGT ALQEISFWLN LERALYRIQE KRESPEVLLT
310 320 330 340 350 360
LDILKHGKRF HATVSFDTDT GLKQALETVN DYNPLMKDFP LNDLLSATEL DKIRQALVAI
370 380 390 400 410 420
FTHLRKIRNT KYPIQRALRL VEAISRDLSS QLLKVLGTRK LMHVAYEEFE KVMVACFEVF
430 440 450 460 470 480
QTWDDEYEKL QVLLRDIVKR KREENLKMVW RINPAHRKLQ ARLDQMRKFR RQHEQLRAVI
490 500 510 520 530 540
VRVLRPQVTA VAQQNQGEVP EPQDMKVAEV LFDAADANAI EEVNLAYENV KEVDGLDVSK
550 560 570 580 590 600
EGTEAWEAAM KRYDERIDRV ETRITARLRD QLGTAKNANE MFRIFSRFNA LFVRPHIRGA
610 620 630 640 650 660
IREYQTQLIQ RVKDDIESLH DKFKVQYPQS QACKMSHVRD LPPVSGSIIW AKQIDRQLTA
670 680 690 700 710 720
YMKRVEDVLG KGWENHVEGQ KLKQDGDSFR MKLNTQEIFD DWARKVQQRN LGVSGRIFTI
730 740 750 760 770 780
ESTRVRGRTG NVLKLKVNFL PEIITLSKEV RNLKWLGFRV PLAIVNKAHQ ANQLYPFAIS
790 800 810 820 830 840
LIESVRTYER TCEKVEERNT ISLLVAGLKK EVQALIAEGI ALVWESYKLD PYVQRLAETV
850 860 870 880 890 900
FNFQEKVDDL LIIEEKIDLE VRSLETCMYD HKTFSEILNR VQKAVDDLNL HSYSNLPIWV
910 920 930 940 950 960
NKLDMEIERI LGVRLQAGLR AWTQVLLGQA EDKAEVDMDT DAPQVSHKPG GEPKIKNVVH
970 980 990 1000 1010 1020
ELRITNQVIY LNPPIEECRY KLYQEMFAWK MVVLSLPRIQ SQRYQVGVHY ELTEEEKFYR
1030 1040 1050 1060 1070 1080
NALTRMPDGP VALEESYSAV MGIVSEVEQY VKVWLQYQCL WDMQAENIYN RLGEDLNKWQ
1090 1100 1110 1120 1130 1140
ALLVQIRKAR GTFDNAETKK EFGPVVIDYG KVQSKVNLKY DSWHKEVLSK FGQMLGSNMT
1150 1160 1170 1180 1190 1200
EFHSQISKSR QELEQHSVDT ASTSDAVTFI TYVQSLKRKI KQFEKQVELY RNGQRLLEKQ
1210 1220 1230 1240 1250 1260
RFQFPPSWLY IDNIEGEWGA FNDIMRRKDS AIQQQVANLQ MKIVQEDRAV ESRTTDLLTD
1270 1280 1290 1300 1310 1320
WEKTKPVTGN LRPEEALQAL TIYEGKFGRL KDDREKCAKA KEALELTDTG LLSGSEERVQ
1330 1340 1350 1360 1370 1380
VALEELQDLK GVWSELSKVW EQIDQMKEQP WVSVQPRKLR QNLDALLNQL KSFPARLRQY
1390 1400 1410 1420 1430 1440
ASYEFVQRLL KGYMKINMLV IELKSEALKD RHWKQLMKRL HVNWVVSELT LGQIWDVDLQ
1450 1460 1470 1480 1490 1500
KNEAIVKDVL LVAQGEMALE EFLKQIREVW NTYELDLVNY QNKCRLIRGW DDLFNKVKEH
1510 1520 1530 1540 1550 1560
INSVSAMKLS PYYKVFEEDA LSWEDKLNRI MALFDVWIDV QRRWVYLEGI FTGSADIKHL
1570 1580 1590 1600 1610 1620
LPVETQRFQS ISTEFLALMK KVSKSPLVMD VLNIQGVQRS LERLADLLGK IQKALGEYLE
1630 1640 1650 1660 1670 1680
RERSSFPRFY FVGDEDLLEI IGNSKNVAKL QKHFKKMFAG VSSIILNEDN SVVLGISSRE
1690 1700 1710 1720 1730 1740
GEEVMFKTPV SITEHPKINE WLTLVEKEMR VTLAKLLAES VTEVEIFGKA TSIDPNTYIT
1750 1760 1770 1780 1790 1800
WIDKYQAQLV VLSAQIAWSE NVETALSSMG GGGDAAPLHS VLSNVEVTLN VLADSVLMEQ
1810 1820 1830 1840 1850 1860
PPLRRRKLEH LITELVHQRD VTRSLIKSKI DNAKSFEWLS QMRFYFDPKQ TDVLQQLSIQ
1870 1880 1890 1900 1910 1920
MANAKFNYGF EYLGVQDKLV QTPLTDRCYL TMTQALEARL GGSPFGPAGT GKTESVKALG
1930 1940 1950 1960 1970 1980
HQLGRFVLVF NCDETFDFQA MGRIFVGLCQ VGAWGCFDEF NRLEERMLSA VSQQVQCIQE
1990 2000 2010 2020 2030 2040
ALREHSNPNY DKTSAPITCE LLNKQVKVSP DMAIFITMNP GYAGRSNLPD NLKKLFRSLA
2050 2060 2070 2080 2090 2100
MTKPDRQLIA QVMLYSQGFR TAEVLANKIV PFFKLCDEQL SSQSHYDFGL RALKSVLVSA
2110 2120 2130 2140 2150 2160
GNVKRERIQK IKREKEERGE AVDEGEIAEN LPEQEILIQS VCETMVPKLV AEDIPLLFSL
2170 2180 2190 2200 2210 2220
LSDVFPGVQY HRGEMTALRE ELKKVCQEMY LTYGDGEEVG GMWVEKVLQL YQITQINHGL
2230 2240 2250 2260 2270 2280
MMVGPSGSGK SMAWRVLLKA LERLEGVEGV AHIIDPKAIS KDHLYGTLDP NTREWTDGLF
2290 2300 2310 2320 2330 2340
THVLRKIIDS VRGELQKRQW IVFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLSLPPNVR
2350 2360 2370 2380 2390 2400
IMFEVQDLKY ATLATVSRCG MVWFSEDVLS TDMIFNNFLA RLRSIPLDEG EDEAQRRRKG
2410 2420 2430 2440 2450 2460
KEDEGEEAAS PMLQIQRDAA TIMQPYFTSN GLVTKALEHA FQLEHIMDLT RLRCLGSLFS
2470 2480 2490 2500 2510 2520
MLHQACRNVA QYNANHPDFP MQIEQLERYI QRYLVYAILW SLSGDSRLKM RAELGEYIRR
2530 2540 2550 2560 2570 2580
ITTVPLPTAP NIPIIDYEVS ISGEWSPWQA KVPQIEVETH KVAAPDVVVP TLDTVRHEAL
2590 2600 2610 2620 2630 2640
LYTWLAEHKP LVLCGPPGSG KTMTLFSALR ALPDMEVVGL NFSSATTPEL LLKTFDHYCE
2650 2660 2670 2680 2690 2700
YRRTPNGVVL APVQLGKWLV LFCDEINLPD MDKYGTQRVI SFIRQMVEHG GFYRTSDQTW
2710 2720 2730 2740 2750 2760
VKLERIQFVG ACNPPTDPGR KPLSHRFLRH VPVVYVDYPG PASLTQIYGT FNRAMLRLIP
2770 2780 2790 2800 2810 2820
SLRTYAEPLT AAMVEFYTMS QERFTQDTQP HYIYSPREMT RWVRGIFEAL RPLETLPVEG
2830 2840 2850 2860 2870 2880
LIRIWAHEAL RLFQDRLVED EERRWTDENI DTVALKHFPN IDREKAMSRP ILYSNWLSKD
2890 2900 2910 2920 2930 2940
YIPVDQEELR DYVKARLKVF YEEELDVPLV LFNEVLDHVL RIDRIFRQPQ GHLLLIGVSG
2950 2960 2970 2980 2990 3000
AGKTTLSRFV AWMNGLSVYQ IKVHRKYTGE DFDEDLRTVL RRSGCKNEKI AFIMDESNVL
3010 3020 3030 3040 3050 3060
DSGFLERMNT LLANGEVPGL FEGDEYATLM TQCKEGAQKE GLMLDSHEEL YKWFTSQVIR
3070 3080 3090 3100 3110 3120
NLHVVFTMNP SSEGLKDRAA TSPALFNRCV LNWFGDWSTE ALYQVGKEFT SKMDLEKPNY
3130 3140 3150 3160 3170 3180
IVPDYMPVVY DKLPQPPSHR EAIVNSCVFV HQTLHQANAR LAKRGGRTMA ITPRHYLDFI
3190 3200 3210 3220 3230 3240
NHYANLFHEK RSELEEQQMH LNVGLRKIKE TVDQVEELRR DLRIKSQELE VKNAAANDKL
3250 3260 3270 3280 3290 3300
KKMVKDQQEA EKKKVMSQEI QEQLHKQQEV IADKQMSVKE DLDKVEPAVI EAQNAVKSIK
3310 3320 3330 3340 3350 3360
KQHLVEVRSM ANPPAAVKLA LESICLLLGE STTDWKQIRS IIMRENFIPT IVNFSAEEIS
3370 3380 3390 3400 3410 3420
DAIREKMKKN YMSNPSYNYE IVNRASLACG PMVKWAIAQL NYADMLKRVE PLRNELQKLE
3430 3440 3450 3460 3470 3480
DDAKDNQQKA NEVEQMIRDL EASIARYKEE YAVLISEAQA IKADLAAVEA KVNRSTALLK
3490 3500 3510 3520 3530 3540
SLSAERERWE KTSETFKNQM STIAGDCLLS AAFIAYAGYF DQQMRQNLFT TWSHHLQQAN
3550 3560 3570 3580 3590 3600
IQFRTDIART EYLSNADERL RWQASSLPAD DLCTENAIML KRFNRYPLII DPSGQATEFI
3610 3620 3630 3640 3650 3660
MNEYKDRKIT RTSFLDDAFR KNLESALRFG NPLLVQDVES YDPVLNPVLN REVRRTGGRV
3670 3680 3690 3700 3710 3720
LITLGDQDID LSPSFVIFLS TRDPTVEFPP DLCSRVTFVN FTVTRSSLQS QCLNEVLKAE
3730 3740 3750 3760 3770 3780
RPDVDEKRSD LLKLQGEFQL RLRQLEKSLL QALNEVKGRI LDDDTIITTL ENLKREAAEV
3790 3800 3810 3820 3830 3840
TRKVEETDIV MQEVETVSQQ YLPLSTACSS IYFTMESLKQ IHFLYQYSLQ FFLDIYHNVL
3850 3860 3870 3880 3890 3900
YENPNLKGVT DHTQRLSIIT KDLFQVAFNR VARGMLHQDH ITFAMLLARI KLKGTVGEPT
3910 3920 3930 3940 3950 3960
YDAEFQHFLR GNEIVLSAGS TPRIQGLTVE QAEAVVRLSC LPAFKDLIAK VQADEQFGIW
3970 3980 3990 4000 4010 4020
LDSSSPEQTV PYLWSEETPA TPIGQAIHRL LLIQAFRPDR LLAMAHMFVS TNLGESFMSI
4030 4040 4050 4060 4070 4080
MEQPLDLTHI VGTEVKPNTP VLMCSVPGYD ASGHVEDLAA EQNTQITSIA IGSAEGFNQA
4090 4100 4110 4120 4130 4140
DKAINTAVKS GRWVMLKNVH LAPGWLMQLE KKLHSLQPHA CFRLFLTMEI NPKVPVNLLR
4150 4160 4170 4180 4190 4200
AGRIFVFEPP PGVKANMLRT FSSIPVSRIC KSPNERARLY FLLAWFHAII QERLRYAPLG
4210 4220 4230 4240 4250 4260
WSKKYEFGES DLRSACDTVD TWLDDTAKGR QNISPDKIPW SALKTLMAQS IYGGRVDNEF
4270 4280 4290 4300 4310 4320
DQRLLNTFLE RLFTTRSFDS EFKLACKVDG HKDIQMPDGI RREEFVQWVE LLPDTQTPSW
4330 4340 4350 4360 4370 4380
LGLPNNAERV LLTTQGVDMI SKMLKMQMLE DEDDLAYAET EKKTRTDSTS DGRPAWMRTL
4390 4400 4410 4420 4430 4440
HTTASNWLHL IPQTLSHLKR TVENIKDPLF RFFEREVKMG AKLLQDVRQD LADVVQVCEG
4450 4460 4470 4480 4490 4500
KKKQTNYLRT LINELVKGIL PRSWSHYTVP AGMTVIQWVS DFSERIKQLQ NISLAAASGG
4510 4520 4530 4540 4550 4560
AKELKNIHVC LGGLFVPEAY ITATRQYVAQ ANSWSLEELC LEVNVTTSQG ATLDACSFGV
4570 4580 4590 4600 4610 4620
TGLKLQGATC NNNKLSLSNA ISTALPLTQL RWVKQTNTEK KASVVTLPVY LNFTRADLIF
4630 4640
TVDFEIATKE DPRSFYERGV AVLCTE
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
10 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q14204-2-unknown | MSEPGG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14204-2-Acetylation | SEPGGG... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q14204-2-Acetylation | SEPGGG... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q14204-2-Acetylation | SEPGGG... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q14204-514- | AADANA... | 514 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14204-514- | AADANA... | 514 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14204-2384- | SIPLDE... | 2384 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14204-2711-unknown | ACNPPT... | 2711 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7829 | |||
Q14204-2711-unknown | ACNPPT... | 2711 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6393 | |||
Q14204-2815-unknown | TLPVEG... | 2815 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6394 | |||
Q14204-3045-unknown | DSHEEL... | 3045 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7830 | |||
Q14204-3258-unknown | QEIQEQ... | 3258 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7831 | |||
Q14204-3765-unknown | TIITTL... | 3765 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19508 | |||
Q14204-4368- | STSDGR... | 4368 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 |
C-termini
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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