O15042: U2 snRNP-associated SURP motif-containing protein
Protein names | - U2 snRNP-associated SURP motif-containing protein - 140 kDa Ser/Arg-rich domain protein - U2-associated protein SR140 |
---|---|
Gene names | U2SURP |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O15042 |
18
N-termini
5
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP RKHNYRNESA
70 80 90 100 110 120
RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE QEELKKKEDE KAAAEIYEEF
130 140 150 160 170 180
LAAFEGSDGN KVKTFVRGGV VNAAKEEHET DEKRGKIYKP SSRFADQKNP PNQSSNERPP
190 200 210 220 230 240
SLLVIETKKP PLKKGEKEKK KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG
250 260 270 280 290 300
QRRSMDAPSR RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350 360
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL GWGKAVPIPP
370 380 390 400 410 420
HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP PPKNKEDFEK TLSQAIVKVV
430 440 450 460 470 480
IPTERNLLAL IHRMIEFVVR EGPMFEAMIM NREINNPMFR FLFENQTPAH VYYRWKLYSI
490 500 510 520 530 540
LQGDSPTKWR TEDFRMFKNG SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD
550 560 570 580 590 600
KLEEILRGLT PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650 660
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV MTCFRAWEDW
670 680 690 700 710 720
AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE EELDGAPLED VDGIPIDATP
730 740 750 760 770 780
IDDLDGVPIK SLDDDLDGVP LDATEDSKKN EPIFKVAPSK WEAVDESELE AQAVTTSKWE
790 800 810 820 830 840
LFDQHEESEE EENQNQEEES EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK
850 860 870 880 890 900
RAKLREIELK VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950 960
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK SERSERSERS
970 980 990 1000 1010 1020
HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS RSPKKSGKKS RSQSRSPHRS
HKKSKKNKH
Isoforms
- Isoform 2 of U2 snRNP-associated SURP motif-containing protein - Isoform 3 of U2 snRNP-associated SURP motif-containing proteinSequence View
10 20 30 40 50 60
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP RKHNYRNESA
70 80 90 100 110 120
RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE QEELKKKEDE KAAAEIYEEF
130 140 150 160 170 180
LAAFEGSDGN KVKTFVRGGV VNAAKEEHET DEKRGKIYKP SSRFADQKNP PNQSSNERPP
190 200 210 220 230 240
SLLVIETKKP PLKKGEKEKK KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG
250 260 270 280 290 300
QRRSMDAPSR RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350 360
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL GWGKAVPIPP
370 380 390 400 410 420
HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP PPKNKEDFEK TLSQAIVKVV
430 440 450 460 470 480
IPTERNLLAL IHRMIEFVVR EGPMFEAMIM NREINNPMFR FLFENQTPAH VYYRWKLYSI
490 500 510 520 530 540
LQGDSPTKWR TEDFRMFKNG SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD
550 560 570 580 590 600
KLEEILRGLT PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650 660
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV MTCFRAWEDW
670 680 690 700 710 720
AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE EELDGAPLED VDGIPIDATP
730 740 750 760 770 780
IDDLDGVPIK SLDDDLDGVP LDATEDSKKN EPIFKVAPSK WEAVDESELE AQAVTTSKWE
790 800 810 820 830 840
LFDQHEESEE EENQNQEEES EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK
850 860 870 880 890 900
RAKLREIELK VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950 960
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK SERSERSERS
970 980 990 1000 1010 1020
HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS RSPKKSGKKS RSQSRSPHRS
HKKSKKNKH
10 20 30 40 50 60
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP RKHNYRNESA
70 80 90 100 110 120
RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE QEELKKKEDE KAAAEIYEEF
130 140 150 160 170 180
LAAFEGSDGN KVKTFVRGGV VNAAKEEHET DEKRGKIYKP SSRFADQKNP PNQSSNERPP
190 200 210 220 230 240
SLLVIETKKP PLKKGEKEKK KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG
250 260 270 280 290 300
QRRSMDAPSR RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350 360
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL GWGKAVPIPP
370 380 390 400 410 420
HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP PPKNKEDFEK TLSQAIVKVV
430 440 450 460 470 480
IPTERNLLAL IHRMIEFVVR EGPMFEAMIM NREINNPMFR FLFENQTPAH VYYRWKLYSI
490 500 510 520 530 540
LQGDSPTKWR TEDFRMFKNG SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD
550 560 570 580 590 600
KLEEILRGLT PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650 660
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV MTCFRAWEDW
670 680 690 700 710 720
AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE EELDGAPLED VDGIPIDATP
730 740 750 760 770 780
IDDLDGVPIK SLDDDLDGVP LDATEDSKKN EPIFKVAPSK WEAVDESELE AQAVTTSKWE
790 800 810 820 830 840
LFDQHEESEE EENQNQEEES EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK
850 860 870 880 890 900
RAKLREIELK VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950 960
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK SERSERSERS
970 980 990 1000 1010 1020
HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS RSPKKSGKKS RSQSRSPHRS
HKKSKKNKH
Protein Neighborhood
Domains & Features
18 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O15042-1-unknown | MADKTP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt90591 | |||
O15042-2-unknown | MADKTP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O15042-2-Acetylation | ADKTPG... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
O15042-2-Acetylation | ADKTPG... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
O15042-2-Acetylation | ADKTPG... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
O15042-2-Acetylation | ADKTPG... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110960 | ||
O15042-69- | HQNLSR... | 69 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O15042-69-unknown | HQNLSR... | 69 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172148 | |||
O15042-143-unknown | AAKEEH... | 143 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18219 | |||
O15042-143-unknown | AAKEEH... | 143 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16869 | |||
O15042-143-unknown | AAKEEH... | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144440 | |||
O15042-208-unknown | KEELKQ... | 208 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O15042-208-unknown | KEELKQ... | 208 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160309 | |||
O15042-208- | KEELKQ... | 208 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O15042-523-unknown | AFVEEP... | 523 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10697 | |||
O15042-523-unknown | AFVEEP... | 523 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143197 | |||
O15042-523-unknown | AFVEEP... | 523 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153640 | |||
O15042-705- | GAPLED... | 705 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O15042-705-unknown | GAPLED... | 705 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176722 | |||
O15042-705-unknown | GAPLED... | 705 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176723 | |||
O15042-713-unknown | GIPIDA... | 713 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166893 | |||
O15042-713-unknown | GIPIDA... | 713 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166894 | |||
O15042-713- | GIPIDA... | 713 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O15042-713- | GIPIDA... | 713 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O15042-713- | GIPIDA... | 713 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O15042-726-unknown | GVPIKS... | 726 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166896 | |||
O15042-726-unknown | GVPIKS... | 726 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166897 | |||
O15042-726- | GVPIKS... | 726 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O15042-726- | GVPIKS... | 726 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O15042-726- | GVPIKS... | 726 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O15042-726- | GVPIKS... | 726 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O15042-738-unknown | GVPLDA... | 738 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1086 | |||
O15042-738-unknown | GVPLDA... | 738 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O15042-738-unknown | GVPLDA... | 738 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150504 | |||
O15042-738-unknown | GVPLDA... | 738 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156178 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_CD95 | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | RMPI_untreated | 23264352 | |||
O15042-738- | GVPLDA... | 738 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O15042-826-unknown | TESKFS... | 826 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13718 | |||
O15042-826-unknown | TESKFS... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152284 | |||
O15042-826-unknown | TESKFS... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156583 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GGVVNA | 142 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18219 | |||
...GGVVNA | 142 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16869 | |||
...GGVVNA | 142 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127704 | |||
...EQETEA | 522 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10697 | |||
...EQETEA | 522 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126423 | |||
...EQETEA | 522 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137064 | |||
...DDDLDG | 737 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1086 | |||
...DDDLDG | 737 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133900 | |||
...DDDLDG | 737 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139644 | |||
...IKEEMT | 825 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13718 | |||
...IKEEMT | 825 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135694 | |||
...IKEEMT | 825 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140068 | |||
...KKNKH | 1029 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KKNKH | 1029 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt86210 | |||
...KKNKH | 1029 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt86209 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1B_HUMAN | 142 | VVNA.|.AAKE | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1A_HUMAN | 142 | VVNA.|.AAKE | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
GRAB_HUMAN | 522 | ETEA.|.AFVE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
CASP1_HUMAN | 737 | DLDG.|.GVPL | inferred from experiment | unknown | MEROPS | Wells JA | Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) | 20173201, |
GRAM_HUMAN | 825 | EEMT.|.TESK | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|