P12956: X-ray repair cross-complementing protein 6

General Information

Protein names	- X-ray repair cross-complementing protein 6 - 3.6.4.- - 4.2.99.- - 5'-deoxyribose-5-phosphate lyase Ku70 - 5'-dRP lyase Ku70 - 70 kDa subunit of Ku antigen - ATP-dependent DNA helicase 2 subunit 1 - ATP-dependent DNA helicase II 70 kDa subunit - CTC box-binding factor 75 kDa subunit - CTC75 - CTCBF - DNA repair protein XRCC6 - Lupus Ku autoantigen protein p70 - Ku70 - Thyroid-lupus autoantigen - TLAA - X-ray repair complementing defective repair in Chinese hamster cells 6
Gene names	XRCC6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12956

13 N-termini

9 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE SQSEDELTPF
        70         80         90        100        110        120
DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK NIYVLQELDN PGAKRILELD
       130        140        150        160        170        180
QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS
       190        200        210        220        230        240
AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE
       250        260        270        280        290        300
DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT
       310        320        330        340        350        360
RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF KPLVLLKKHH
       370        380        390        400        410        420
YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF VALVPQEEEL
       430        440        450        460        470        480
DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR FTYRSDSFEN
       490        500        510        520        530        540
PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV
       550        560        570        580        590        600
TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL

EALTKHFQD

Isoforms

- Isoform 2 of X-ray repair cross-complementing protein 6

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 9 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12956-2-unknown	MSGWES...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12956-2-Acetylation	SGWESY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12956-2-Acetylation	SGWESY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P12956-80-unknown	RDLLAV...	80		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11197
P12956-96-	SVNFKN...	96			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P12956-134-unknown	MMGHGS...	134		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000403679
P12956-302-unknown	TFNTST...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9990
P12956-302-	TFNTST...	302			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P12956-302-	TFNTST...	302			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P12956-306-unknown	STGGLL...	306		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3637
P12956-331-unknown	KEETEE...	331		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7303
P12956-411-unknown	VALVPQ...	411		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3638
P12956-479-unknown	ENPVLQ...	479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18713
P12956-502-unknown	QAVDLT...	502		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11198
P12956-511-	VEAMNK...	511			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IISSDR	79	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11197
...KTKTRT	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9990
...RTFNTS	305	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3637
...QIILEK	330	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7303
...IPPYFV	410	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3638
...RSDSFE	478	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18713
...LMEPEQ	501	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11198
...KHFQD	609		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KHFQD	609	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KHFQD	609		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	79	SSDR.\|.RDLL	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
GRAA_HUMAN	301	KTRT.\|.TFNT	inferred from experiment	unknown	MEROPS	Lieberman J	Zhu P et al.:Granzyme A, which causes single... (S01.135)	16440001,
CATB_HUMAN	305	FNTS.\|.STGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	330	ILEK.\|.KEET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	410	PYFV.\|.VALV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	478	DSFE.\|.ENPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	501	EPEQ.\|.QAVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)