P06576: ATP synthase subunit beta, mitochondrial {ECO:0000305}

General Information

Protein names	- ATP synthase subunit beta, mitochondrial {ECO:0000305} - 7.1.2.2 - ATP synthase F1 subunit beta {ECO:0000312\|HGNC:HGNC:830}
Gene names	ATP5B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06576

22 N-termini

9 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT
        70         80         90        100        110        120
GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV
       130        140        150        160        170        180
RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ
       190        200        210        220        230        240
EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT
       250        260        270        280        290        300
REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD
       310        320        330        340        350        360
VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI
       370        380        390        400        410        420
YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV
       430        440        450        460        470        480
ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK
       490        500        510        520
LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

22 N-termini - 9 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06576-1-acetylation	MLGFVG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P06576-37-unknown	PTAVHP...	37			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-37-	PTAVHP...	37			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P06576-47-	AAQTSP...	47			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06576-47-unknown	AAQTSP...	47			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-47-unknown	AAQTSP...	47			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-48-	AQTSPS...	48			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06576-48-	AQTSPS...	48			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-48-	AQTSPS...	48			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06576-48-	AQTSPS...	48			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06576-48-unknown	AQTSPS...	48		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06576-48-unknown	AQTSPS...	48			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-48-unknown	AQTSPS...	48			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-50-	TSPSPK...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-111-	IAMDGT...	111			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06576-111-	IAMDGT...	111			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-111-	IAMDGT...	111			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06576-111-	IAMDGT...	111			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06576-111-unknown	IAMDGT...	111			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06576-134-unknown	IPVGPE...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17151
P06576-134-unknown	IPVGPE...	134		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06576-134-unknown	IPVGPE...	134		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P06576-146-	NVIGEP...	146			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-177-	SVEQEI...	177			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-208-unknown	AGVGKT...	208		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448428
P06576-249-unknown	EMIESG...	249		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18521
P06576-312-	TQAGSE...	312			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06576-356-	SVQAIY...	356			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P06576-356-	SVQAIY...	356			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06576-359-	AIYVPA...	359			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P06576-360-	IYVPAD...	360			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-360-	IYVPAD...	360			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06576-360-	IYVPAD...	360			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06576-397-	AVDPLD...	397			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06576-415-unknown	SEHYDV...	415		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7206
P06576-464-	LSQPFQ...	464			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GAPIKI	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17151
...NDLYHE	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18521
...DDLTDP	369	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447571
...LSRAIA	389	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448428
...PNIVGS	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7206
...ARGVQK	425	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446489
...SQPFQV	469	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446677
...GPIEEA	515	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450233
...EEHSS	529	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	133	PIKI.\|.IPVG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	248	LYHE.\|.EMIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	414	IVGS.\|.SEHY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)