P12004: Proliferating cell nuclear antigen

General Information

Protein names	- Proliferating cell nuclear antigen - PCNA - Cyclin
Gene names	PCNA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12004

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY
        70         80         90        100        110        120
RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD
       130        140        150        160        170        180
LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI
       190        200        210        220        230        240
KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK
       250        260
IADMGHLKYY LAPKIEDEEG S

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12004-1-unknown	MFEARL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12004-83-	GNEDII...	83		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P12004-100-	ALVFEA...	100		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P12004-132-unknown	EYSCVV...	132	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18705

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GIPEQE	131	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18705
	...DEEGS	261	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	131	PEQE.\|.EYSC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)