Q9Y490: Talin-1
Protein names | - Talin-1 |
---|---|
Gene names | TLN1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9Y490 |
20
N-termini
8
C-termini
8
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI
70 80 90 100 110 120
WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG
130 140 150 160 170 180
ITNHDEYSLV RELMEEKKEE ITGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL
190 200 210 220 230 240
REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG
250 260 270 280 290 300
FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK
310 320 330 340 350 360
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA
370 380 390 400 410 420
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML
430 440 450 460 470 480
EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM
490 500 510 520 530 540
HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFDTLP PLGQDAASKA WRKNKMDESK
550 560 570 580 590 600
HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED
610 620 630 640 650 660
EGGSGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT
670 680 690 700 710 720
DPHFQDALMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT QVIAAATQCA LSTSQLVACT
730 740 750 760 770 780
KVVAPTISSP VCQEQLVEAG RLVAKAVEGC VSASQAATED GQLLRGVGAA ATAVTQALNE
790 800 810 820 830 840
LLQHVKAHAT GAGPAGRYDQ ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI
850 860 870 880 890 900
KADAEGESDL ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA
910 920 930 940 950 960
TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS TPKASAGPQP LLVQSCKAVA
970 980 990 1000 1010 1020
EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM VAAAKASVPT IQDQASAMQL
1030 1040 1050 1060 1070 1080
SQCAKNLGTA LAELRTAAQK AQEACGPLEM DSALSVVQNL EKDLQEVKAA ARDGKLKPLP
1090 1100 1110 1120 1130 1140
GETMEKCTQD LGNSTKAVSS AIAQLLGEVA QGNENYAGIA ARDVAGGLRS LAQAARGVAA
1150 1160 1170 1180 1190 1200
LTSDPAVQAI VLDTASDVLD KASSLIEEAK KAAGHPGDPE SQQRLAQVAK AVTQALNRCV
1210 1220 1230 1240 1250 1260
SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN QAATELVQAS
1270 1280 1290 1300 1310 1320
RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ VVSNLKGISM SSSKLLLAAK
1330 1340 1350 1360 1370 1380
ALSTDPAAPN LKSQLAAAAR AVTDSINQLI TMCTQQAPGQ KECDNALREL ETVRELLENP
1390 1400 1410 1420 1430 1440
VQPINDMSYF GCLDSVMENS KVLGEAMTGI SQNAKNGNLP EFGDAISTAS KALCGFTEAA
1450 1460 1470 1480 1490 1500
AQAAYLVGVS DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK
1510 1520 1530 1540 1550 1560
HTSALCNSCR LASARTTNPT AKRQFVQSAK EVANSTANLV KTIKALDGAF TEENRAQCRA
1570 1580 1590 1600 1610 1620
ATAPLLEAVD NLSAFASNPE FSSIPAQISP EGRAAMEPIV ISAKTMLESA GGLIQTARAL
1630 1640 1650 1660 1670 1680
AVNPRDPPSW SVLAGHSRTV SDSIKKLITS MRDKAPGQLE CETAIAALNS CLRDLDQASL
1690 1700 1710 1720 1730 1740
AAVSQQLAPR EGISQEALHT QMLTAVQEIS HLIEPLANAA RAEASQLGHK VSQMAQYFEP
1750 1760 1770 1780 1790 1800
LTLAAVGAAS KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV
1810 1820 1830 1840 1850 1860
QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGEPEGSF VDYQTTMVRT
1870 1880 1890 1900 1910 1920
AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASEA KPAAVAAENE EIGSHIKHRV
1930 1940 1950 1960 1970 1980
QELGHGCAAL VTKAGALQCS PSDAYTKKEL IECARRVSEK VSHVLAALQA GNRGTQACIT
1990 2000 2010 2020 2030 2040
AASAVSGIIA DLDTTIMFAT AGTLNREGTE TFADHREGIL KTAKVLVEDT KVLVQNAAGS
2050 2060 2070 2080 2090 2100
QEKLAQAAQS SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA
2110 2120 2130 2140 2150 2160
AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT EHIRQELAVF
2170 2180 2190 2200 2210 2220
CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED VIATANLSRR AIADMLRACK
2230 2240 2250 2260 2270 2280
EAAYHPEVAP DVRLRALHYG RECANGYLEL LDHVLLTLQK PSPELKQQLT GHSKRVAGSV
2290 2300 2310 2320 2330 2340
TELIQAAEAM KGTEWVDPED PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN
2350 2360 2370 2380 2390 2400
FEEQILEAAK SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV
2410 2420 2430 2440 2450 2460
AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS EAMKRLQAAG
2470 2480 2490 2500 2510 2520
NAVKRASDNL VKAAQKAAAF EEQENETVVV KEKMVGGIAQ IIAAQEEMLR KERELEEARK
2530 2540
KLAQIRQQQY KFLPSELRDE H
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
20 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9Y490-1-unknown | MVALSL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9Y490-100- | IMVDDS... | 100 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9Y490-206- | SRDPVQ... | 206 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9Y490-247-unknown | FGPHNE... | 247 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6943 | |||
Q9Y490-247-unknown | FGPHNE... | 247 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8159 | |||
Q9Y490-428- | KSTVLQ... | 428 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q9Y490-428-unknown | KSTVLQ... | 428 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9Y490-466- | GSMPPA... | 466 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9Y490-467- | SMPPAQ... | 467 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9Y490-467-unknown | SMPPAQ... | 467 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9Y490-467-unknown | SMPPAQ... | 467 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9Y490-576- | AVTTIS... | 576 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9Y490-576- | AVTTIS... | 576 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9Y490-576- | AVTTIS... | 576 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q9Y490-576- | AVTTIS... | 576 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9Y490-769-unknown | AAATAV... | 769 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6944 | |||
Q9Y490-832-unknown | ATSDLV... | 832 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4301 | |||
Q9Y490-839-unknown | AIKADA... | 839 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q9Y490-900-unknown | ATNAAA... | 900 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q9Y490-932-unknown | IAAAQH... | 932 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4302 | |||
Q9Y490-1199-unknown | CVSCLP... | 1199 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q9Y490-1288-unknown | MAGQAP... | 1288 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4303 | |||
Q9Y490-1568- | AVDNLS... | 1568 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9Y490-1712-unknown | LIEPLA... | 1712 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19881 | |||
Q9Y490-1925-unknown | HGCAAL... | 1925 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6945 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QCQIQF | 246 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6943 | |||
...QCQIQF | 246 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8159 | |||
...LRGVGA | 768 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6944 | |||
...RILAQA | 831 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4301 | |||
...SATQTI | 931 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4302 | |||
...EAGVEM | 1287 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4303 | |||
...QEISHL | 1711 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19881 | |||
...VQELGH | 1924 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6945 | |||
...LRDEH | 2541 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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