Q01813: ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255|HAMAP-Rule:MF_03184}

General Information

Protein names	- ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255\|HAMAP-Rule:MF_03184} - ATP-PFK {ECO:0000255\|HAMAP-Rule:MF_03184} - PFK-P - 2.7.1.11 {ECO:0000255\|HAMAP-Rule:MF_03184} - 6-phosphofructokinase type C - Phosphofructo-1-kinase isozyme C - PFK-C - Phosphohexokinase {ECO:0000255\|HAMAP-Rule:MF_03184}
Gene names	PFKP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01813

15 N-termini

12 C-termini

12 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 6-phosphofructokinase type C - Isoform 2 of ATP-dependent 6-phosphofructokinase, platelet type

Sequence View

        10         20         30         40         50         60
MDADDSRAPK GSLRKFLEHL SGAGKAIGVL TSGGDAQGMN AAVRAVVRMG IYVGAKVYFI
        70         80         90        100        110        120
YEGYQGMVDG GSNIAEADWE SVSSILQVGG TIIGSARCQA FRTREGRLKA ACNLLQRGIT
       130        140        150        160        170        180
NLCVIGGDGS LTGANLFRKE WSGLLEELAR NGQIDKEAVQ KYAYLNVVGM VGSIDNDFCG
       190        200        210        220        230        240
TDMTIGTDSA LHRIIEVVDA IMTTAQSHQR TFVLEVMGRH CGYLALVSAL ACGADWVFLP
       250        260        270        280        290        300
ESPPEEGWEE QMCVKLSENR ARKKRLNIII VAEGAIDTQN KPITSEKIKE LVVTQLGYDT
       310        320        330        340        350        360
RVTILGHVQR GGTPSAFDRI LASRMGVEAV IALLEATPDT PACVVSLNGN HAVRLPLMEC
       370        380        390        400        410        420
VQMTQDVQKA MDERRFQDAV RLRGRSFAGN LNTYKRLAIK LPDDQIPKTN CNVAVINVGA
       430        440        450        460        470        480
PAAGMNAAVR SAVRVGIADG HRMLAIYDGF DGFAKGQIKE IGWTDVGGWT GQGGSILGTK
       490        500        510        520        530        540
RVLPGKYLEE IATQMRTHSI NALLIIGGFE AYLGLLELSA AREKHEEFCV PMVMVPATVS
       550        560        570        580        590        600
NNVPGSDFSI GADTALNTIT DTCDRIKQSA SGTKRRVFII ETMGGYCGYL ANMGGLAAGA
       610        620        630        640        650        660
DAAYIFEEPF DIRDLQSNVE HLTEKMKTTI QRGLVLRNES CSENYTTDFI YQLYSEEGKG
       670        680        690        700        710        720
VFDCRKNVLG HMQQGGAPSP FDRNFGTKIS ARAMEWITAK LKEARGRGKK FTTDDSICVL
       730        740        750        760        770        780
GISKRNVIFQ PVAELKKQTD FEHRIPKEQW WLKLRPLMKI LAKYKASYDV SDSGQLEHVQ

PWSV         10         20         30         40         50         60
MDADDSRAPK GSLRKFLEHL SGAGKAIGVL TSGGDAQGMN AAVRAVVRMG IYVGAKVYFI
        70         80         90        100        110        120
YEGYQGMVDG GSNIAEADWE SVSSILQVGG TIIGSARCQA FRTREGRLKA ACNLLQRGIT
       130        140        150        160        170        180
NLCVIGGDGS LTGANLFRKE WSGLLEELAR NGQIDKEAVQ KYAYLNVVGM VGSIDNDFCG
       190        200        210        220        230        240
TDMTIGTDSA LHRIIEVVDA IMTTAQSHQR TFVLEVMGRH CGYLALVSAL ACGADWVFLP
       250        260        270        280        290        300
ESPPEEGWEE QMCVKLSENR ARKKRLNIII VAEGAIDTQN KPITSEKIKE LVVTQLGYDT
       310        320        330        340        350        360
RVTILGHVQR GGTPSAFDRI LASRMGVEAV IALLEATPDT PACVVSLNGN HAVRLPLMEC
       370        380        390        400        410        420
VQMTQDVQKA MDERRFQDAV RLRGRSFAGN LNTYKRLAIK LPDDQIPKTN CNVAVINVGA
       430        440        450        460        470        480
PAAGMNAAVR SAVRVGIADG HRMLAIYDGF DGFAKGQIKE IGWTDVGGWT GQGGSILGTK
       490        500        510        520        530        540
RVLPGKYLEE IATQMRTHSI NALLIIGGFE AYLGLLELSA AREKHEEFCV PMVMVPATVS
       550        560        570        580        590        600
NNVPGSDFSI GADTALNTIT DTCDRIKQSA SGTKRRVFII ETMGGYCGYL ANMGGLAAGA
       610        620        630        640        650        660
DAAYIFEEPF DIRDLQSNVE HLTEKMKTTI QRGLVLRNES CSENYTTDFI YQLYSEEGKG
       670        680        690        700        710        720
VFDCRKNVLG HMQQGGAPSP FDRNFGTKIS ARAMEWITAK LKEARGRGKK FTTDDSICVL
       730        740        750        760        770        780
GISKRNVIFQ PVAELKKQTD FEHRIPKEQW WLKLRPLMKI LAKYKASYDV SDSGQLEHVQ

PWSV

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 12 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01813-1-Acetylation	MDADDS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01813-26-	AIGVLT...	26			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01813-32-unknown	SGGDAQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6211
Q01813-129-unknown	GSLTGA...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11879
Q01813-129-unknown	GSLTGA...	129		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143516
Q01813-129-unknown	GSLTGA...	129		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01813-129-unknown	GSLTGA...	129		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q01813-169-	GMVGSI...	169			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01813-169-unknown	GMVGSI...	169		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177930
Q01813-185-unknown	IGTDSA...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7721
Q01813-185-unknown	IGTDSA...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145782
Q01813-358-unknown	MECVQM...	358		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14357
Q01813-358-unknown	MECVQM...	358		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150927
Q01813-420-unknown	APAAGM...	420		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19315
Q01813-420-unknown	APAAGM...	420		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152190
Q01813-446-unknown	IYDGFD...	446		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6212
Q01813-446-unknown	IYDGFD...	446		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152599
Q01813-554-unknown	TALNTI...	554		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11881
Q01813-554-unknown	TALNTI...	554		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153950
Q01813-557-unknown	NTITDT...	557		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11883
Q01813-557-unknown	NTITDT...	557		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153981
Q01813-602-unknown	AAYIFE...	602		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11885
Q01813-602-unknown	AAYIFE...	602		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154516
Q01813-617-unknown	SNVEHL...	617		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7723
Q01813-617-unknown	SNVEHL...	617		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6214
Q01813-617-unknown	SNVEHL...	617		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154724
Q01813-715-unknown	DSICVL...	715		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11887
Q01813-715-unknown	DSICVL...	715		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155913

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IGVLTS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6211
...VIGGDG	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11879
...VIGGDG	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126756
...GTDMTI	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7721
...GTDMTI	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129079
...VRLPLM	357	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14357
...VRLPLM	357	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134329
...VINVGA	419	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19315
...VINVGA	419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135600
...HRMLAI	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6212
...HRMLAI	445	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136016
...SIGADT	553	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11881
...SIGADT	553	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137372
...ADTALN	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11883
...ADTALN	556	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137402
...AAGADA	601	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11885
...AAGADA	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137938
...IRDLQS	616	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7723
...IRDLQS	616	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6214
...IRDLQS	616	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138150
...KFTTDD	714	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11887
...KFTTDD	714	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139370
...QPWSV	784	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QPWSV	784	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74109

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	31	VLTS.\|.SGGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	128	GGDG.\|.GSLT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	184	DMTI.\|.IGTD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	357	LPLM.\|.MECV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	419	NVGA.\|.APAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	445	MLAI.\|.IYDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	553	GADT.\|.TALN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	556	TALN.\|.NTIT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	601	GADA.\|.AAYI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	616	DLQS.\|.SNVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	616	DLQS.\|.SNVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	714	TTDD.\|.DSIC	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)