P49327: Fatty acid synthase

General Information

Protein names	- Fatty acid synthase - 2.3.1.85 - Acyl-carrier-protein] S-acetyltransferase - 2.3.1.38 - Acyl-carrier-protein] S-malonyltransferase - 2.3.1.39 - 3-oxoacyl-acyl-carrier-protein] synthase - 2.3.1.41 - 3-oxoacyl-acyl-carrier-protein] reductase - 1.1.1.100 - 3-hydroxyacyl-acyl-carrier-protein] dehydratase - 4.2.1.59 - Enoyl-acyl-carrier-protein] reductase - 1.3.1.39 - Oleoyl-acyl-carrier-protein] hydrolase - 3.1.2.14
Gene names	FASN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49327

31 N-termini

20 C-termini

22 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEVVIAGMS GKLPESENLQ EFWDNLIGGV DMVTDDDRRW KAGLYGLPRR SGKLKDLSRF
        70         80         90        100        110        120
DASFFGVHPK QAHTMDPQLR LLLEVTYEAI VDGGINPDSL RGTHTGVWVG VSGSETSEAL
       130        140        150        160        170        180
SRDPETLVGY SMVGCQRAMM ANRLSFFFDF RGPSIALDTA CSSSLMALQN AYQAIHSGQC
       190        200        210        220        230        240
PAAIVGGINV LLKPNTSVQF LRLGMLSPEG TCKAFDTAGN GYCRSEGVVA VLLTKKSLAR
       250        260        270        280        290        300
RVYATILNAG TNTDGFKEQG VTFPSGDIQE QLIRSLYQSA GVAPESFEYI EAHGTGTKVG
       310        320        330        340        350        360
DPQELNGITR ALCATRQEPL LIGSTKSNMG HPEPASGLAA LAKVLLSLEH GLWAPNLHFH
       370        380        390        400        410        420
SPNPEIPALL DGRLQVVDQP LPVRGGNVGI NSFGFGGSNV HIILRPNTQP PPAPAPHATL
       430        440        450        460        470        480
PRLLRASGRT PEAVQKLLEQ GLRHSQDLAF LSMLNDIAAV PATAMPFRGY AVLGGERGGP
       490        500        510        520        530        540
EVQQVPAGER PLWFICSGMG TQWRGMGLSL MRLDRFRDSI LRSDEAVKPF GLKVSQLLLS
       550        560        570        580        590        600
TDESTFDDIV HSFVSLTAIQ IGLIDLLSCM GLRPDGIVGH SLGEVACGYA DGCLSQEEAV
       610        620        630        640        650        660
LAAYWRGQCI KEAHLPPGAM AAVGLSWEEC KQRCPPGVVP ACHNSKDTVT ISGPQAPVFE
       670        680        690        700        710        720
FVEQLRKEGV FAKEVRTGGM AFHSYFMEAI APPLLQELKK VIREPKPRSA RWLSTSIPEA
       730        740        750        760        770        780
QWHSSLARTS SAEYNVNNLV SPVLFQEALW HVPEHAVVLE IAPHALLQAV LKRGLKPSCT
       790        800        810        820        830        840
IIPLMKKDHR DNLEFFLAGI GRLHLSGIDA NPNALFPPVE FPAPRGTPLI SPLIKWDHSL
       850        860        870        880        890        900
AWDVPAAEDF PNGSGSPSAA IYNIDTSSES PDHYLVDHTL DGRVLFPATG YLSIVWKTLA
       910        920        930        940        950        960
RALGLGVEQL PVVFEDVVLH QATILPKTGT VSLEVRLLEA SRAFEVSENG NLVVSGKVYQ
       970        980        990       1000       1010       1020
WDDPDPRLFD HPESPTPNPT EPLFLAQAEV YKELRLRGYD YGPHFQGILE ASLEGDSGRL
      1030       1040       1050       1060       1070       1080
LWKDNWVSFM DTMLQMSILG SAKHGLYLPT RVTAIHIDPA THRQKLYTLQ DKAQVADVVV
      1090       1100       1110       1120       1130       1140
SRWLRVTVAG GVHISGLHTE SAPRRQQEQQ VPILEKFCFT PHTEEGCLSE RAALQEELQL
      1150       1160       1170       1180       1190       1200
CKGLVQALQT KVTQQGLKMV VPGLDGAQIP RDPSQQELPR LLSAACRLQL NGNLQLELAQ
      1210       1220       1230       1240       1250       1260
VLAQERPKLP EDPLLSGLLD SPALKACLDT AVENMPSLKM KVVEVLAGHG HLYSRIPGLL
      1270       1280       1290       1300       1310       1320
SPHPLLQLSY TATDRHPQAL EAAQAELQQH DVAQGQWDPA DPAPSALGSA DLLVCNCAVA
      1330       1340       1350       1360       1370       1380
ALGDPASALS NMVAALREGG FLLLHTLLRG HPLGDIVAFL TSTEPQYGQG ILSQDAWESL
      1390       1400       1410       1420       1430       1440
FSRVSLRLVG LKKSFYGSTL FLCRRPTPQD SPIFLPVDDT SFRWVESLKG ILADEDSSRP
      1450       1460       1470       1480       1490       1500
VWLKAINCAT SGVVGLVNCL RREPGGNRLR CVLLSNLSST SHVPEVDPGS AELQKVLQGD
      1510       1520       1530       1540       1550       1560
LVMNVYRDGA WGAFRHFLLE EDKPEEPTAH AFVSTLTRGD LSSIRWVCSS LRHAQPTCPG
      1570       1580       1590       1600       1610       1620
AQLCTVYYAS LNFRDIMLAT GKLSPDAIPG KWTSQDSLLG MEFSGRDASG KRVMGLVPAK
      1630       1640       1650       1660       1670       1680
GLATSVLLSP DFLWDVPSNW TLEEAASVPV VYSTAYYALV VRGRVRPGET LLIHSGSGGV
      1690       1700       1710       1720       1730       1740
GQAAIAIALS LGCRVFTTVG SAEKRAYLQA RFPQLDSTSF ANSRDTSFEQ HVLWHTGGKG
      1750       1760       1770       1780       1790       1800
VDLVLNSLAE EKLQASVRCL ATHGRFLEIG KFDLSQNHPL GMAIFLKNVT FHGVLLDAFF
      1810       1820       1830       1840       1850       1860
NESSADWREV WALVQAGIRD GVVRPLKCTV FHGAQVEDAF RYMAQGKHIG KVVVQVLAEE
      1870       1880       1890       1900       1910       1920
PEAVLKGAKP KLMSAISKTF CPAHKSYIIA GGLGGFGLEL AQWLIQRGVQ KLVLTSRSGI
      1930       1940       1950       1960       1970       1980
RTGYQAKQVR RWRRQGVQVQ VSTSNISSLE GARGLIAEAA QLGPVGGVFN LAVVLRDGLL
      1990       2000       2010       2020       2030       2040
ENQTPEFFQD VCKPKYSGTL NLDRVTREAC PELDYFVVFS SVSCGRGNAG QSNYGFANSA
      2050       2060       2070       2080       2090       2100
MERICEKRRH EGLPGLAVQW GAIGDVGILV ETMSTNDTIV SGTLPQRMAS CLEVLDLFLN
      2110       2120       2130       2140       2150       2160
QPHMVLSSFV LAEKAAAYRD RDSQRDLVEA VAHILGIRDL AAVNLDSSLA DLGLDSLMSV
      2170       2180       2190       2200       2210       2220
EVRQTLEREL NLVLSVREVR QLTLRKLQEL SSKADEASEL ACPTPKEDGL AQQQTQLNLR
      2230       2240       2250       2260       2270       2280
SLLVNPEGPT LMRLNSVQSS ERPLFLVHPI EGSTTVFHSL ASRLSIPTYG LQCTRAAPLD
      2290       2300       2310       2320       2330       2340
SIHSLAAYYI DCIRQVQPEG PYRVAGYSYG ACVAFEMCSQ LQAQQSPAPT HNSLFLFDGS
      2350       2360       2370       2380       2390       2400
PTYVLAYTQS YRAKLTPGCE AEAETEAICF FVQQFTDMEH NRVLEALLPL KGLEERVAAA
      2410       2420       2430       2440       2450       2460
VDLIIKSHQG LDRQELSFAA RSFYYKLRAA EQYTPKAKYH GNVMLLRAKT GGAYGEDLGA
      2470       2480       2490       2500       2510
DYNLSQVCDG KVSVHVIEGD HRTLLEGSGL ESIISIIHSS LAEPRVSVRE G

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

31 N-termini - 20 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49327-1-Acetylation	MEEVVI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49327-1-Acetylation	MEEVVI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P49327-113-unknown	GSETSE...	113		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5919
P49327-255-	GFKEQG...	255			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-263-unknown	FPSGDI...	263		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5920
P49327-279-unknown	SAGVAP...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5921
P49327-279-unknown	SAGVAP...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3808
P49327-288-unknown	EYIEAH...	288		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19147
P49327-331-unknown	HPEPAS...	331		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19148
P49327-456-unknown	DIAAVP...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19149
P49327-690-unknown	IAPPLL...	690		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17676
P49327-716-	SIPEAQ...	716			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-863-	NIDTSS...	863			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49327-958-	VYQWDD...	958			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-1090-unknown	GGVHIS...	1090		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7503
P49327-1094-unknown	ISGLHT...	1094		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3809
P49327-1108-unknown	EQQVPI...	1108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19150
P49327-1120-unknown	TPHTEE...	1120		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5922
P49327-1152-	VTQQGL...	1152			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P49327-1159-	MVVPGL...	1159			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-1166-	GAQIPR...	1166			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49327-1166-	GAQIPR...	1166			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49327-1166-	GAQIPR...	1166			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49327-1166-	GAQIPR...	1166			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49327-1166-	GAQIPR...	1166			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-1247-unknown	AGHGHL...	1247		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5923
P49327-1430-	GILADE...	1430			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-1436-unknown	DSSRPV...	1436		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19151
P49327-1479-	STSHVP...	1479			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-1479-unknown	STSHVP...	1479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5924
P49327-1479-unknown	STSHVP...	1479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7504
P49327-1526-unknown	EPTAHA...	1526		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19152
P49327-1856-unknown	VLAEEP...	1856		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5925
P49327-2221-	SLLVNP...	2221			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49327-2221-	SLLVNP...	2221			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49327-2221-	SLLVNP...	2221			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-2224-unknown	VNPEGP...	2224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7505
P49327-2224-unknown	VNPEGP...	2224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19153
P49327-2236-	SVQSSE...	2236			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49327-2236-	SVQSSE...	2236			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49327-2374-unknown	QFTDME...	2374		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7506
P49327-2462-unknown	YNLSQV...	2462		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11587

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WVGVSG	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5919
...EQGVTF	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5920
...RSLYQS	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5921
...RSLYQS	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3808
...APESFE	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19147
...KSNMGH	330	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19148
...LSMLND	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19149
...YFMEAI	689	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17676
...RVTVAG	1089	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7503
...AGGVHI	1093	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3809
...PRRQQE	1107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19150
...EKFCFT	1119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5922
...VVEVLA	1246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5923
...ILADED	1435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19151
...LSNLSS	1478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5924
...LSNLSS	1478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7504
...EDKPEE	1525	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19152
...KVVVQV	1855	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5925
...LRSLLV	2223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7505
...LRSLLV	2223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19153
...CFFVQQ	2373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7506
...DLGADY	2461	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11587
...SVREG	2511	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	112	GVSG.\|.GSET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	262	GVTF.\|.FPSG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	278	LYQS.\|.SAGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	278	LYQS.\|.SAGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	287	ESFE.\|.EYIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	330	NMGH.\|.HPEP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	455	MLND.\|.DIAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	689	MEAI.\|.IAPP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	1089	TVAG.\|.GGVH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	1093	GVHI.\|.ISGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	1107	RQQE.\|.EQQV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	1119	FCFT.\|.TPHT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1246	EVLA.\|.AGHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	1435	ADED.\|.DSSR	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	1478	NLSS.\|.STSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1478	NLSS.\|.STSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	1525	KPEE.\|.EPTA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	1855	VVQV.\|.VLAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	2223	SLLV.\|.VNPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	2223	SLLV.\|.VNPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	2373	FVQQ.\|.QFTD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	2461	GADY.\|.YNLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)