Q13547: Histone deacetylase 1 {ECO:0000305}

General Information

Protein names	- Histone deacetylase 1 {ECO:0000305} - HD1 - 3.5.1.98
Gene names	HDAC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13547

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
        70         80         90        100        110        120
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS
       130        140        150        160        170        180
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
       190        200        210        220        230        240
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
       250        260        270        280        290        300
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
       310        320        330        340        350        360
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
       370        380        390        400        410        420
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF
       430        440        450        460        470        480
SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK

LA

Isoforms

Sequence View

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Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13547-1-unknown	MAQTQG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13547-78-	SIRPDN...	78		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13547-78-	SIRPDN...	78		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13547-78-	SIRPDN...	78		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13547-83-unknown	NMSEYS...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12093
Q13547-182-	GVEEAF...	182		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13547-194-unknown	MTVSFH...	194	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000362642
Q13547-238-unknown	EAIFKP...	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19464
Q13547-383-	AIPEDA...	383		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13547-388-	AIPEES...	388		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SIRPDN	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12093
...IDDESY	236	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407859
...DDESYE	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19464
...EVKLA	482	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	82	RPDN.\|.NMSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	237	ESYE.\|.EAIF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)