O14950: Myosin regulatory light chain 12B

General Information

Protein names	- Myosin regulatory light chain 12B - MLC-2A - MLC-2 - Myosin regulatory light chain 2-B, smooth muscle isoform - Myosin regulatory light chain 20 kDa - MLC20 - Myosin regulatory light chain MRLC2 - SHUJUN-1
Gene names	MYL12B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14950

5 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS
        70         80         90        100        110        120
LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE
       130        140        150        160        170
DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14950-1-unknown	MSSKKA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14950-2-acetylation	SSKKAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O14950-2-acetylation	SSKKAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O14950-96-	GTDPED...	96			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14950-145-unknown	EAPIDK...	145		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18214
O14950-146-unknown	APIDKK...	146		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18215

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DELYRE	144	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18214
...ELYREA	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18215
...KDKDD	172	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KDKDD	172		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KDKDD	172		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	144	LYRE.\|.EAPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	145	YREA.\|.APID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)