Q16891: MICOS complex subunit MIC60

General Information

Protein names	- MICOS complex subunit MIC60 - Cell proliferation-inducing gene 4/52 protein - Mitochondrial inner membrane protein - Mitofilin - p87/89
Gene names	IMMT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16891

14 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mitochondrial inner membrane protein - Isoform 3 of Mitochondrial inner membrane protein - Isoform 4 of Mitochondrial inner membrane protein - Isoform 2 of MICOS complex subunit MIC60 - Isoform 3 of MICOS complex subunit MIC60 - Isoform 4 of MICOS complex subunit MIC60

Sequence View

        10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE         10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE         10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE         10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE         10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE         10         20         30         40         50         60
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
        70         80         90        100        110        120
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
       130        140        150        160        170        180
SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
       190        200        210        220        230        240
PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
       250        260        270        280        290        300
AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
       310        320        330        340        350        360
ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
       370        380        390        400        410        420
LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
       430        440        450        460        470        480
EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
       490        500        510        520        530        540
TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
       550        560        570        580        590        600
TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
       610        620        630        640        650        660
ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
       670        680        690        700        710        720
SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
       730        740        750
AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16891-1-unknown	MLRACQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16891-1-unknown	MLRACQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77848
Q16891-1-unknown	MLRACQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77849
Q16891-1-unknown	MLRACQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77850
Q16891-33-unknown	YSTSGS...	33		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16891-33-unknown	YSTSGS...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159816
Q16891-33-unknown	YSTSGS...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159817
Q16891-33-unknown	YSTSGS...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159818
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q16891-33-	YSTSGS...	33		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q16891-34-	STSGSS...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16891-34-unknown	STSGSS...	34		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16891-34-unknown	STSGSS...	34		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16891-34-unknown	STSGSS...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159812
Q16891-34-unknown	STSGSS...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159813
Q16891-34-unknown	STSGSS...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159814
Q16891-34-unknown	STSGSS...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16891-157-	SVPAPA...	157		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16891-157-unknown	SVPAPA...	157	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175056
Q16891-157-unknown	SVPAPA...	157	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175054
Q16891-157-unknown	SVPAPA...	157	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175055
Q16891-176-	IGEGKP...	176		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q16891-176-unknown	IGEGKP...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165148
Q16891-238-	AIAAQN...	238		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16891-238-unknown	AIAAQN...	238	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177745
Q16891-238-unknown	AIAAQN...	238	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177746
Q16891-238-unknown	AIAAQN...	238	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177744
Q16891-244-unknown	AAVQAV...	244	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19606
Q16891-244-unknown	AAVQAV...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147060
Q16891-244-unknown	AAVQAV...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147839
Q16891-244-unknown	AAVQAV...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148213
Q16891-375-unknown	SITPEV...	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175059
Q16891-375-unknown	SITPEV...	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175060
Q16891-375-unknown	SITPEV...	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175058
Q16891-375-	SITPEV...	375		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IAAQNA	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19606
...IAAQNA	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130393
...IAAQNA	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131193
...IAAQNA	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131580
...QVQPE	758	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QVQPE	758	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73467
...QVQPE	758	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73466
...QVQPE	758	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73468

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	243	AQNA.\|.AAVQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)