P61081: NEDD8-conjugating enzyme Ubc12

General Information

Protein names	- NEDD8-conjugating enzyme Ubc12 - 2.3.2.- - NEDD8 carrier protein - Ubiquitin-conjugating enzyme E2 M
Gene names	UBE2M
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61081

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF
        70         80         90        100        110        120
KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK
       130        140        150        160        170        180
PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER

CLK

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61081-1-Acetylation	MIKLFS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61081-1-unknown	MIKLFS...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P61081-60-unknown	FKLVIC...	60		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469855
P61081-84-unknown	QGYPHD...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6075
P61081-84-unknown	QGYPHD...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7613
P61081-98-unknown	MVYHPN...	98		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468940

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SFKVGQ	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6075
...SFKVGQ	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7613
...QNVQRS	166	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468940
...ERCLK	183	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	83	KVGQ.\|.QGYP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	83	KVGQ.\|.QGYP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)