Q9BYJ9: YTH domain-containing family protein 1 {ECO:0000305}
Protein names | - YTH domain-containing family protein 1 {ECO:0000305} - Dermatomyositis associated with cancer putative autoantigen 1 {ECO:0000303|Ref.4} - DACA-1 {ECO:0000303|Ref.4} |
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Gene names | YTHDF1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9BYJ9 |
11
N-termini
4
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS MSDPYLSSYY
70 80 90 100 110 120
PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYQHRF
130 140 150 160 170 180
NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM
190 200 210 220 230 240
NSLEQGMVGL KIGDVSSSAV KTVGSVVSSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK
250 260 270 280 290 300
PAKPQPKMKT KSGPVMGGGL PPPPIKHNMD IGTWDNKGPV PKAPVPQQAP SPQAAPQPQQ
310 320 330 340 350 360
VAQPLPAQPP ALAQPQYQSP QQPPQTRWVA PRNRNAAFGQ SGGAGSDSNS PGNVQPNSAP
370 380 390 400 410 420
SVESHPVLEK LKAAHSYNPK EFEWNLKSGR VFIIKSYSED DIHRSIKYSI WCSTEHGNKR
430 440 450 460 470 480
LDSAFRCMSS KGPVYLLFSV NGSGHFCGVA EMKSPVDYGT SAGVWSQDKW KGKFDVQWIF
490 500 510 520 530 540
VKDVPNNQLR HIRLENNDNK PVTNSRDTQE VPLEKAKQVL KIISSYKHTT SIFDDFAHYE
550
KRQEEEEVVR KERQSRNKQ
Isoforms
- Isoform 2 of YTH domain-containing family protein 1Sequence View
10 20 30 40 50 60
MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS MSDPYLSSYY
70 80 90 100 110 120
PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYQHRF
130 140 150 160 170 180
NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM
190 200 210 220 230 240
NSLEQGMVGL KIGDVSSSAV KTVGSVVSSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK
250 260 270 280 290 300
PAKPQPKMKT KSGPVMGGGL PPPPIKHNMD IGTWDNKGPV PKAPVPQQAP SPQAAPQPQQ
310 320 330 340 350 360
VAQPLPAQPP ALAQPQYQSP QQPPQTRWVA PRNRNAAFGQ SGGAGSDSNS PGNVQPNSAP
370 380 390 400 410 420
SVESHPVLEK LKAAHSYNPK EFEWNLKSGR VFIIKSYSED DIHRSIKYSI WCSTEHGNKR
430 440 450 460 470 480
LDSAFRCMSS KGPVYLLFSV NGSGHFCGVA EMKSPVDYGT SAGVWSQDKW KGKFDVQWIF
490 500 510 520 530 540
VKDVPNNQLR HIRLENNDNK PVTNSRDTQE VPLEKAKQVL KIISSYKHTT SIFDDFAHYE
550
KRQEEEEVVR KERQSRNKQ
Protein Neighborhood
Domains & Features
11 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9BYJ9-2-unknown | MSATSV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9BYJ9-2-Acetylation | SATSVD... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q9BYJ9-2-Acetylation | SATSVD... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9BYJ9-2-Acetylation | SATSVD... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9BYJ9-103-unknown | AVFGQP... | 103 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1347 | |||
Q9BYJ9-104- | VFGQPG... | 104 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q9BYJ9-160-unknown | GTVVDG... | 160 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6757 | |||
Q9BYJ9-165-unknown | GQPGFH... | 165 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q9BYJ9-165- | GQPGFH... | 165 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q9BYJ9-165- | GQPGFH... | 165 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9BYJ9-165- | GQPGFH... | 165 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q9BYJ9-165- | GQPGFH... | 165 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9BYJ9-165- | GQPGFH... | 165 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9BYJ9-316- | QYQSPQ... | 316 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9BYJ9-316-unknown | QYQSPQ... | 316 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172318 | |||
Q9BYJ9-358- | SAPSVE... | 358 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9BYJ9-358-unknown | SAPSVE... | 358 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172320 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...HFMHDA | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1347 | |||
...PSSLGG | 159 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6757 | |||
...NPKEFE | 382 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt90511 | |||
...SRNKQ | 559 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP1_HUMAN | 102 | MHDA.|.AVFG | inferred from experiment | unknown | MEROPS | Wells JA | Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) | 20173201, |
CATL1_HUMAN | 159 | SLGG.|.GTVV | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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