Q13148: TAR DNA-binding protein 43

General Information

Protein names	- TAR DNA-binding protein 43 - TDP-43
Gene names	TARDBP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13148

9 N-termini

9 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI
        70         80         90        100        110        120
LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL
       130        140        150        160        170        180
KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS
       190        200        210        220        230        240
KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA
       250        260        270        280        290        300
QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG
       310        320        330        340        350        360
NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ
       370        380        390        400        410
REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM

Isoforms

- Isoform 2 of TAR DNA-binding protein 43

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13148-1-unknown	MSEYIR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13148-33-unknown	AQFPGA...	33	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6310
Q13148-84-	KMDETD...	84		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13148-90-	ASSAVK...	90		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13148-90-unknown	ASSAVK...	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2161
Q13148-90-unknown	ASSAVK...	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2956
Q13148-170-unknown	GRWCDC...	170	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2162
Q13148-170-unknown	GRWCDC...	170	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2957
Q13148-307-unknown	MGGGMN...	307	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14402
Q13148-341-unknown	ASQQNQ...	341	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7757
Q13148-342-unknown	SQQNQS...	342	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7758
Q13148-342-unknown	SQQNQS...	342	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6311

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LSTVTA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6310
...MDETDA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2161
...MDETDA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2956
...RHMIDG	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2162
...RHMIDG	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2957
...LPNSKQ	181	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466842
...RCTEDM	201	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465240
...NQGSNM	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14402
...MMGMLA	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7757
...MGMLAS	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7758
...MGMLAS	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6311
...SGWGM	414	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	32	TVTA.\|.AQFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	89	ETDA.\|.ASSA	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> TADBP_HUMAN @89
CASP7_HUMAN	89	ETDA.\|.ASSA	inferred from experiment	unknown	MEROPS	Matsuoka M	Suzuki H et al.:TDP-43-induced death is associa... (C14.003)	21339291,
CASP3_HUMAN	169	MIDG.\|.GRWC	inferred from experiment	unknown	MEROPS	Matsuoka M	Suzuki H et al.:TDP-43-induced death is associa... (C14.003)	21339291,
CASP7_HUMAN	169	MIDG.\|.GRWC	inferred from experiment	unknown	MEROPS	Matsuoka M	Suzuki H et al.:TDP-43-induced death is associa... (C14.003)	21339291,
GRAM_HUMAN	306	GSNM.\|.MGGG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	340	GMLA.\|.ASQQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	341	MLAS.\|.SQQN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	341	MLAS.\|.SQQN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)