P00568: Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}

General Information

Protein names	- Adenylate kinase isoenzyme 1 {ECO:0000255\|HAMAP-Rule:MF_03171} - AK 1 {ECO:0000255\|HAMAP-Rule:MF_03171} - 2.7.4.3 {ECO:0000255\|HAMAP-Rule:MF_03171} - 2.7.4.6 {ECO:0000255\|HAMAP-Rule:MF_03171} - ATP-AMP transphosphorylase 1 {ECO:0000255\|HAMAP-Rule:MF_03171} - ATP:AMP phosphotransferase {ECO:0000255\|HAMAP-Rule:MF_03171} - Adenylate monophosphate kinase {ECO:0000255\|HAMAP-Rule:MF_03171} - Myokinase {ECO:0000255\|HAMAP-Rule:MF_03171}
Gene names	AK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00568

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEKLKKTKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRSEVSSG SARGKKLSEI
        70         80         90        100        110        120
MEKGQLVPLE TVLDMLRDAM VAKVNTSKGF LIDGYPREVQ QGEEFERRIG QPTLLLYVDA
       130        140        150        160        170        180
GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD
       190
SVFSQVCTHL DALK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P00568-1-Acetylation	MEEKLK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00568-36-unknown	HLSTGD...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5323
P00568-98-Pyrrolidone carboxylic acid (Glu)	EVQQGE...	98	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00568-98-	EVQQGE...	98			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KYGYTH	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5323
	...LDALK	194	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	35	GYTH.\|.HLST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)