P00441: Superoxide dismutase [Cu-Zn]

General Information

Protein names	- Superoxide dismutase Cu-Zn] - 1.15.1.1 - Superoxide dismutase 1 - hSod1
Gene names	SOD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00441

23 N-termini

15 C-termini

24 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS
        70         80         90        100        110        120
AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV
       130        140        150
HEKADDLGKG GNEESTKTGN AGSRLACGVI GIAQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

23 N-termini - 15 C-termini - 24 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00441-2-unknown	MATKAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00441-2-Acetylation	ATKAVC...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00441-2-Acetylation	ATKAVC...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00441-6-	VCVLKG...	6			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00441-11-unknown	GDGPVQ...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5303
P00441-11-unknown	GDGPVQ...	11		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00441-11-unknown	GDGPVQ...	11		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P00441-17-unknown	GIINFE...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7090
P00441-17-unknown	GIINFE...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5304
P00441-17-unknown	GIINFE...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3308
P00441-41-unknown	EGLHGF...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7091
P00441-41-unknown	EGLHGF...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5305
P00441-45-unknown	GFHVHE...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7092
P00441-45-unknown	GFHVHE...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5306
P00441-46-unknown	FHVHEF...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3309
P00441-55-	TAGCTS...	55			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P00441-58-unknown	CTSAGP...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5307
P00441-58-unknown	CTSAGP...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3310
P00441-60-	SAGPHF...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P00441-60-	SAGPHF...	60			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P00441-60-unknown	SAGPHF...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7093
P00441-60-unknown	SAGPHF...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5308
P00441-61-unknown	AGPHFN...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7094
P00441-61-unknown	AGPHFN...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5309
P00441-85-	LGNVTA...	85			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00441-102-	DSVISL...	102			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00441-102-acetylation	DSVISL...	102	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00441-103-unknown	SVISLS...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1118
P00441-107-unknown	LSGDHC...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16984
P00441-107-unknown	LSGDHC...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7095
P00441-107-unknown	LSGDHC...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5310
P00441-107-unknown	LSGDHC...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3311
P00441-108-unknown	SGDHCI...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7096
P00441-109-unknown	GDHCII...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7097
P00441-109-unknown	GDHCII...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5311
P00441-119-	VVHEKA...	119			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P00441-124-	ADDLGK...	124			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P00441-124-	ADDLGK...	124			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P00441-126-unknown	DLGKGG...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16985

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VCVLKG	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5303
...DGPVQG	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7090
...DGPVQG	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5304
...DGPVQG	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3308
...IKGLTE	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7091
...IKGLTE	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5305
...TEGLHG	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7092
...TEGLHG	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5306
...EGLHGF	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3309
...DNTAGC	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5307
...DNTAGC	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3310
...TAGCTS	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7093
...TAGCTS	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5308
...AGCTSA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7094
...AGCTSA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5309
...VSIEDS	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1118
...DSVISL	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16984
...DSVISL	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7095
...DSVISL	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5310
...DSVISL	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3311
...SVISLS	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7096
...VISLSG	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7097
...VISLSG	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5311
...HEKADD	125	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16985
...IGIAQ	154	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...IGIAQ	154		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IGIAQ	154		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...IGIAQ	154		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IGIAQ	154		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	10	VLKG.\|.GDGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	16	PVQG.\|.GIIN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	16	PVQG.\|.GIIN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	16	PVQG.\|.GIIN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	40	GLTE.\|.EGLH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	40	GLTE.\|.EGLH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	44	GLHG.\|.GFHV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	44	GLHG.\|.GFHV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	45	LHGF.\|.FHVH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	57	TAGC.\|.CTSA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	57	TAGC.\|.CTSA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	59	GCTS.\|.SAGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	59	GCTS.\|.SAGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	60	CTSA.\|.AGPH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	60	CTSA.\|.AGPH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP1_HUMAN	102	IEDS.\|.SVIS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
MEP1A_HUMAN	106	VISL.\|.LSGD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	106	VISL.\|.LSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	106	VISL.\|.LSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	106	VISL.\|.LSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	107	ISLS.\|.SGDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	108	SLSG.\|.GDHC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	108	SLSG.\|.GDHC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	125	KADD.\|.DLGK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)