P52306: Rap1 GTPase-GDP dissociation stimulator 1

General Information

Protein names	- Rap1 GTPase-GDP dissociation stimulator 1 - Exchange factor smgGDS - SMG GDS protein - SMG P21 stimulatory GDP/GTP exchange protein
Gene names	RAP1GDS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52306

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rap1 GTPase-GDP dissociation stimulator 1 - Isoform 3 of Rap1 GTPase-GDP dissociation stimulator 1 - Isoform 4 of Rap1 GTPase-GDP dissociation stimulator 1 - Isoform 5 of Rap1 GTPase-GDP dissociation stimulator 1 - Isoform 6 of Rap1 GTPase-GDP dissociation stimulator 1

Sequence View

        10         20         30         40         50         60
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
        70         80         90        100        110        120
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
       130        140        150        160        170        180
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
       190        200        210        220        230        240
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
       250        260        270        280        290        300
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
       310        320        330        340        350        360
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
       370        380        390        400        410        420
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
       430        440        450        460        470        480
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
       490        500        510        520        530        540
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
       550        560        570        580        590        600
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES         10         20         30         40         50         60
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
        70         80         90        100        110        120
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
       130        140        150        160        170        180
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
       190        200        210        220        230        240
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
       250        260        270        280        290        300
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
       310        320        330        340        350        360
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
       370        380        390        400        410        420
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
       430        440        450        460        470        480
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
       490        500        510        520        530        540
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
       550        560        570        580        590        600
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES         10         20         30         40         50         60
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
        70         80         90        100        110        120
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
       130        140        150        160        170        180
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
       190        200        210        220        230        240
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
       250        260        270        280        290        300
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
       310        320        330        340        350        360
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
       370        380        390        400        410        420
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
       430        440        450        460        470        480
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
       490        500        510        520        530        540
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
       550        560        570        580        590        600
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES         10         20         30         40         50         60
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
        70         80         90        100        110        120
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
       130        140        150        160        170        180
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
       190        200        210        220        230        240
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
       250        260        270        280        290        300
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
       310        320        330        340        350        360
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
       370        380        390        400        410        420
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
       430        440        450        460        470        480
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
       490        500        510        520        530        540
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
       550        560        570        580        590        600
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES         10         20         30         40         50         60
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
        70         80         90        100        110        120
QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
       130        140        150        160        170        180
HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
       190        200        210        220        230        240
VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
       250        260        270        280        290        300
REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
       310        320        330        340        350        360
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
       370        380        390        400        410        420
KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
       430        440        450        460        470        480
KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
       490        500        510        520        530        540
DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
       550        560        570        580        590        600
LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52306-1-unknown	MDNLSD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52306-1-unknown	MDNLSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75870
P52306-432-unknown	AQAEAA...	432	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5993
P52306-432-unknown	AQAEAA...	432	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150757
P52306-432-unknown	AQAEAA...	432	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151700
P52306-432-unknown	AQAEAA...	432	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151714
P52306-432-unknown	AQAEAA...	432	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152522
P52306-496-unknown	VTMATS...	496	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168952
P52306-496-unknown	VTMATS...	496	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168956
P52306-496-unknown	VTMATS...	496	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168955
P52306-496-unknown	VTMATS...	496	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168954
P52306-496-unknown	VTMATS...	496	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168953
P52306-496-	VTMATS...	496		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RMLIDA	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5993
...RMLIDA	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134157
...RMLIDA	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135104
...RMLIDA	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135118
...RMLIDA	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135933
...LTVES	607	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTVES	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71492
...LTVES	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71488
...LTVES	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71489
...LTVES	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71490
...LTVES	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71491

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	431	LIDA.\|.AQAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)