P52292: Importin subunit alpha-1 {ECO:0000305}

General Information

Protein names	- Importin subunit alpha-1 {ECO:0000305} - Karyopherin subunit alpha-2 - RAG cohort protein 1 - SRP1-alpha
Gene names	KPNA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52292

6 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR RNVSSFPDDA
        70         80         90        100        110        120
TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA RKLLSREKQP PIDNIIRAGL
       130        140        150        160        170        180
IPKFVSFLGR TDCSPIQFES AWALTNIASG TSEQTKAVVD GGAIPAFISL LASPHAHISE
       190        200        210        220        230        240
QAVWALGNIA GDGSVFRDLV IKYGAVDPLL ALLAVPDMSS LACGYLRNLT WTLSNLCRNK
       250        260        270        280        290        300
NPAPPIDAVE QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK
       310        320        330        340        350        360
LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN IQKEATWTMS
       370        380        390        400        410        420
NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA VTNYTSGGTV EQIVYLVHCG
       430        440        450        460        470        480
IIEPLMNLLT AKDTKIILVI LDAISNIFQA AEKLGETEKL SIMIEECGGL DKIEALQNHE
       490        500        510        520
NESVYKASLS LIEKYFSVEE EEDQNVVPET TSEGYTFQVQ DGAPGTFNF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52292-1-acetylation	MSTNEN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52292-1-acetylation	MSTNEN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52292-2-unknown	MSTNEN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52292-2-Acetylation	STNENA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52292-2-Acetylation	STNENA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52292-2-Acetylation	STNENA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52292-40-unknown	KAKKDD...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10096
P52292-59-	DATSPL...	59			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52292-188-unknown	NIAGDG...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5992

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVELRK	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10096
...RTDCSP	134	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463602
...RTDCSP	134	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464196
...ESAWAL	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462331
...ESAWAL	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462234
...VWALGN	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5992
...GTFNF	529	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	39	ELRK.\|.KAKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	187	ALGN.\|.NIAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)