Q96B26: Exosome complex component RRP43

General Information

Protein names	- Exosome complex component RRP43 - Exosome component 8 - Opa-interacting protein 2 - OIP-2 - Ribosomal RNA-processing protein 43 - p9
Gene names	EXOSC8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96B26

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL VKLGNTTVIC
        70         80         90        100        110        120
GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE EAQVASQFIA DVIENSQIIQ
       130        140        150        160        170        180
KEDLCISPGK LVWVLYCDLI CLDYDGNILD ACTFALLAAL KNVQLPEVTI NEETALAEVN
       190        200        210        220        230        240
LKKKSYLNIR THPVATSFAV FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG
       250        260        270
SGLTGAKLQD CMSRAVTRHK EVKKLMDEVI KSMKPK

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96B26-2-unknown	MAAGFK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96B26-2-Acetylation	AAGFKT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96B26-2-Acetylation	AAGFKT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96B26-2-Acetylation	AAGFKT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96B26-41-unknown	SISTAD...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6657
Q96B26-132-unknown	VWVLYC...	132		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419203

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TVNIGS	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6657
	...SMKPK	276	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	40	NIGS.\|.SIST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)