P24752: Acetyl-CoA acetyltransferase, mitochondrial

General Information

Protein names	- Acetyl-CoA acetyltransferase, mitochondrial - 2.3.1.9 {ECO:0000255\|PROSITE-ProRule:PRU10020, ECO:0000269\|PubMed:1715688, ECO:0000269\|PubMed:17371050, ECO:0000269\|PubMed:7728148, ECO:0000269\|PubMed:9744475} - Acetoacetyl-CoA thiolase - T2
Gene names	ACAT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P24752

8 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVLAALLRS GARSRSPLLR RLVQEIRYVE RSYVSKPTLK EVVIVSATRT PIGSFLGSLS
        70         80         90        100        110        120
LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG QAPTRQAVLG AGLPISTPCT
       130        140        150        160        170        180
TINKVCASGM KAIMMASQSL MCGHQDVMVA GGMESMSNVP YVMNRGSTPY GGVKLEDLIV
       190        200        210        220        230        240
KDGLTDVYNK IHMGSCAENT AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV
       250        260        270        280        290        300
TVKGQPDVVV KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA
       310        320        330        340        350        360
AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW EVNEAFSLVV
       370        380        390        400        410        420
LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH ALKQGEYGLA SICNGGGGAS

AMLIQKL

Isoforms

- Isoform 2 of Acetyl-CoA acetyltransferase, mitochondrial

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P24752-32-	SYVSKP...	32		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P24752-34-	VSKPTL...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P24752-34-	VSKPTL...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P24752-34-	VSKPTL...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P24752-34-	VSKPTL...	34		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P24752-34-	VSKPTL...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P24752-34-unknown	VSKPTL...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P24752-34-unknown	VSKPTL...	34		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P24752-34-unknown	VSKPTL...	34		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P24752-34-unknown	VSKPTL...	34	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P24752-91-unknown	MGNVLQ...	91	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433568
P24752-96-unknown	QGGEGQ...	96	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5720
P24752-96-unknown	QGGEGQ...	96	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7384
P24752-110-unknown	GAGLPI...	110	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3725
P24752-213-unknown	AYAINS...	213	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11351
P24752-244-	GQPDVV...	244		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P24752-244-	GQPDVV...	244		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P24752-244-	GQPDVV...	244		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MGNVLQ	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5720
...MGNVLQ	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7384
...RQAVLG	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3725
...LMCGHQ	144	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433568
...RNEQDA	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11351
...LIQKL	427	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	95	NVLQ.\|.QGGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	95	NVLQ.\|.QGGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	109	AVLG.\|.GAGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	212	EQDA.\|.AYAI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)