P36507: Dual specificity mitogen-activated protein kinase kinase 2

General Information

Protein names	- Dual specificity mitogen-activated protein kinase kinase 2 - MAP kinase kinase 2 - MAPKK 2 - 2.7.12.2 {ECO:0000269\|PubMed:10409742} - ERK activator kinase 2 - MAPK/ERK kinase 2 - MEK 2
Gene names	MAP2K2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36507

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ
        70         80         90        100        110        120
KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ
       130        140        150        160        170        180
VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG
       190        200        210        220        230        240
LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ
       250        260        270        280        290        300
GTHYSVQSDI WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP
       310        320        330        340        350        360
PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL IKNPAERADL
       370        380        390        400
KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P36507-1-Acetylation	MLARRK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36507-13-	TINPTI...	13			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P36507-98-unknown	MARKLI...	98		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000378336
P36507-281-unknown	RPVVDG...	281		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5822

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EAIFGR	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5822
	...TRTAV	400	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	280	IFGR.\|.RPVV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)