P54136: Arginine--tRNA ligase, cytoplasmic

General Information

Protein names	- Arginine--tRNA ligase, cytoplasmic - 6.1.1.19 {ECO:0000269\|PubMed:16055448, ECO:0000269\|PubMed:25288775} - Arginyl-tRNA synthetase - ArgRS
Gene names	RARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54136

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK LKYRLNILRK
        70         80         90        100        110        120
SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL LVTPSQQAKF GDYQCNSAMG
       130        140        150        160        170        180
ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC IEKVEIAGPG FINVHLRKDF VSEQLTSLLV
       190        200        210        220        230        240
NGVQLPALGE NKKVIVDFSS PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD
       250        260        270        280        290        300
WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK
       310        320        330        340        350        360
NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE DRGFVQVDDG
       370        380        390        400        410        420
RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK ADMIIYVVDN GQSVHFQTIF
       430        440        450        460        470        480
AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK KFKTRSGETV RLMDLLGEGL KRSMDKLKEK
       490        500        510        520        530        540
ERDKVLTAEE LNAAQTSVAY GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR
       550        560        570        580        590        600
IRSIARLANI DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY
       610        620        630        640        650        660
IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD ILGIKPVQRM

Isoforms

- Isoform Monomeric of Arginine--tRNA ligase, cytoplasmic

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54136-1-Acetylation	MDVLVS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54136-1-Acetylation	MDVLVS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54136-1-Acetylation	MDVLVS...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P54136-1-Acetylation	MDVLVS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P54136-2-But	DVLVSE...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54136-37-unknown	ASPNLE...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6025
P54136-73-unknown	MINIIS...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91260
P54136-185-unknown	LPALGE...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6026
P54136-185-unknown	LPALGE...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143126

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CGCLGA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6025
...VNGVQL	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6026
...VNGVQL	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126348
...PVQRM	660	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PVQRM	660	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86878

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	36	CLGA.\|.ASPN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	184	GVQL.\|.LPAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)