O43491: Band 4.1-like protein 2
Protein names | - Band 4.1-like protein 2 - Generally expressed protein 4.1 - 4.1G |
---|---|
Gene names | EPB41L2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O43491 |
17
N-termini
2
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR
70 80 90 100 110 120
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE
130 140 150 160 170 180
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET
190 200 210 220 230 240
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG
250 260 270 280 290 300
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350 360
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE
370 380 390 400 410 420
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK
430 440 450 460 470 480
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA
490 500 510 520 530 540
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE
550 560 570 580 590 600
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650 660
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP
670 680 690 700 710 720
EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP
730 740 750 760 770 780
GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE
790 800 810 820 830 840
PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE
850 860 870 880 890 900
EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950 960
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI
970 980 990 1000
TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED
Isoforms
- Isoform 2 of Band 4.1-like protein 2 - Isoform 3 of Band 4.1-like protein 2 - Isoform 4 of Band 4.1-like protein 2Sequence View
10 20 30 40 50 60
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR
70 80 90 100 110 120
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE
130 140 150 160 170 180
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET
190 200 210 220 230 240
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG
250 260 270 280 290 300
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350 360
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE
370 380 390 400 410 420
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK
430 440 450 460 470 480
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA
490 500 510 520 530 540
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE
550 560 570 580 590 600
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650 660
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP
670 680 690 700 710 720
EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP
730 740 750 760 770 780
GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE
790 800 810 820 830 840
PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE
850 860 870 880 890 900
EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950 960
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI
970 980 990 1000
TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED
10 20 30 40 50 60
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR
70 80 90 100 110 120
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE
130 140 150 160 170 180
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET
190 200 210 220 230 240
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG
250 260 270 280 290 300
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350 360
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE
370 380 390 400 410 420
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK
430 440 450 460 470 480
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA
490 500 510 520 530 540
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE
550 560 570 580 590 600
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650 660
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP
670 680 690 700 710 720
EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP
730 740 750 760 770 780
GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE
790 800 810 820 830 840
PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE
850 860 870 880 890 900
EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950 960
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI
970 980 990 1000
TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED
10 20 30 40 50 60
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR
70 80 90 100 110 120
RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE
130 140 150 160 170 180
EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET
190 200 210 220 230 240
QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG
250 260 270 280 290 300
QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350 360
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE
370 380 390 400 410 420
FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK
430 440 450 460 470 480
LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA
490 500 510 520 530 540
AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE
550 560 570 580 590 600
RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650 660
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP
670 680 690 700 710 720
EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP
730 740 750 760 770 780
GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE
790 800 810 820 830 840
PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE
850 860 870 880 890 900
EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950 960
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI
970 980 990 1000
TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED
Protein Neighborhood
Domains & Features
17 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O43491-2-unknown | MTTEVG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O43491-1-unknown | MTTEVG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73530 | |||
O43491-1-unknown | MTTEVG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73531 | |||
O43491-1-unknown | MTTEVG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73532 | |||
O43491-2-Acetylation | TTEVGS... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
O43491-2-Acetylation | TTEVGS... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
O43491-2-Acetylation | TTEVGS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111743 | ||
O43491-2-Acetylation | TTEVGS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111744 | ||
O43491-2-Acetylation | TTEVGS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111745 | ||
O43491-87-unknown | SYTLVV... | 87 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O43491-87-unknown | SYTLVV... | 87 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159607 | |||
O43491-87-unknown | SYTLVV... | 87 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159608 | |||
O43491-87-unknown | SYTLVV... | 87 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159609 | |||
O43491-87- | SYTLVV... | 87 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O43491-96-unknown | GGDKKE... | 96 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171937 | |||
O43491-96-unknown | GGDKKE... | 96 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171938 | |||
O43491-96-unknown | GGDKKE... | 96 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171939 | |||
O43491-96- | GGDKKE... | 96 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O43491-96- | GGDKKE... | 96 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O43491-384- | GLSPAQ... | 384 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O43491-384-unknown | GLSPAQ... | 384 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177727 | |||
O43491-384-unknown | GLSPAQ... | 384 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177728 | |||
O43491-384-unknown | GLSPAQ... | 384 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177729 | |||
O43491-553- | GAPIGV... | 553 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O43491-553-unknown | GAPIGV... | 553 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175784 | |||
O43491-553-unknown | GAPIGV... | 553 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175785 | |||
O43491-553-unknown | GAPIGV... | 553 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175786 | |||
O43491-711-unknown | GKEISP... | 711 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172497 | |||
O43491-711- | GKEISP... | 711 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O43491-806- | SVITVE... | 806 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O43491-913- | GGAGGD... | 913 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O43491-913-unknown | GGAGGD... | 913 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177725 | |||
O43491-913-unknown | GGAGGD... | 913 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177724 | |||
O43491-935-unknown | TTTTTH... | 935 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5167 | |||
O43491-935-unknown | TTTTTH... | 935 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7019 | |||
O43491-935-unknown | TTTTTH... | 935 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155624 | |||
O43491-935-unknown | TTTTTH... | 935 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156430 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SESVST | 934 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5167 | |||
...SESVST | 934 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7019 | |||
...SESVST | 934 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139066 | |||
...SESVST | 934 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139910 | |||
...EEGED | 1005 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EEGED | 1005 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69148 | |||
...EEGED | 1005 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69149 | |||
...EEGED | 1005 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69150 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 934 | SVST.|.TTTT | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATS_HUMAN | 934 | SVST.|.TTTT | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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