P04632: Calpain small subunit 1

General Information

Protein names	- Calpain small subunit 1 - CSS1 - Calcium-activated neutral proteinase small subunit - CANP small subunit - Calcium-dependent protease small subunit - CDPS - Calcium-dependent protease small subunit 1 - Calpain regulatory subunit
Gene names	CAPNS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04632

21 N-termini

8 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR
        70         80         90        100        110        120
ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL
       130        140        150        160        170        180
MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ
       190        200        210        220        230        240
FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF
       250        260
RAFKSLDKDG TGQIQVNIQE WLQLTMYS

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

21 N-termini - 8 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04632-1-Acetylation	MFLVNS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04632-1-Acetylation	MFLVNS...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P04632-31-	GLISGA...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04632-33-	ISGAGG...	33			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-34-unknown	SGAGGG...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7199
P04632-35-unknown	GAGGGG...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5388
P04632-35-unknown	GAGGGG...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7200
P04632-39-unknown	GGGGGG...	39		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5389
P04632-61-acetylation	ILGGVI...	61	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-63-	GGVISA...	63			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-64-	GVISAI...	64			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04632-65-	VISAIS...	65			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P04632-68-	AISEAA...	68			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04632-68-	AISEAA...	68			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-68-unknown	AISEAA...	68			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P04632-72-	AAAQYN...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04632-75-	QYNPEP...	75			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04632-85-	THYSNI...	85			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-85-acetylation	THYSNI...	85	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-87-	YSNIEA...	87			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-88-	SNIEAN...	88			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04632-92-unknown	ANESEE...	92			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P04632-113-unknown	MEVSAT...	113		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475159
P04632-113-unknown	MEVSAT...	113		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04632-113-unknown	MEVSAT...	113		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P04632-136-	TDGFGI...	136			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGGLIS	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7199
...GGLISG	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5388
...GGLISG	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7200
...SGAGGG	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5389
...AISEAA	72	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468591
...LGFEEF	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466386
...HLYNMI	212	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475159
...DFDNFI	229	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475804
...LTMYS	268	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	33	GLIS.\|.SGAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	34	LISG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	34	LISG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	38	AGGG.\|.GGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)