TopFIND 4.0

Q9NR22: Protein arginine N-methyltransferase 8 {ECO:0000305}

General Information

Protein names
- Protein arginine N-methyltransferase 8 {ECO:0000305}
- 2.1.1.319 {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}
- 2.1.1.321 {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}
- Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
Gene names PRMT8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9NR22

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGMKHSSRCL LLRRKMAENA AESTEVNSPP SQPPQPVVPA KPVQCVHHVS TQPSCPGRGK 
        70         80         90        100        110        120 
MSKLLNPEEM TSRDYYFDSY AHFGIHEEML KDEVRTLTYR NSMYHNKHVF KDKVVLDVGS 
       130        140        150        160        170        180 
GTGILSMFAA KAGAKKVFGI ECSSISDYSE KIIKANHLDN IITIFKGKVE EVELPVEKVD 
       190        200        210        220        230        240 
IIISEWMGYC LFYESMLNTV IFARDKWLKP GGLMFPDRAA LYVVAIEDRQ YKDFKIHWWE 
       250        260        270        280        290        300 
NVYGFDMTCI RDVAMKEPLV DIVDPKQVVT NACLIKEVDI YTVKTEELSF TSAFCLQIQR 
       310        320        330        340        350        360 
NDYVHALVTY FNIEFTKCHK KMGFSTAPDA PYTHWKQTVF YLEDYLTVRR GEEIYGTISM 
       370        380        390    
KPNAKNVRDL DFTVDLDFKG QLCETSVSND YKMR

Isoforms

- Isoform 2 of Protein arginine N-methyltransferase 8

Sequence View

        10         20         30         40         50         60 
MGMKHSSRCL LLRRKMAENA AESTEVNSPP SQPPQPVVPA KPVQCVHHVS TQPSCPGRGK 
        70         80         90        100        110        120 
MSKLLNPEEM TSRDYYFDSY AHFGIHEEML KDEVRTLTYR NSMYHNKHVF KDKVVLDVGS 
       130        140        150        160        170        180 
GTGILSMFAA KAGAKKVFGI ECSSISDYSE KIIKANHLDN IITIFKGKVE EVELPVEKVD 
       190        200        210        220        230        240 
IIISEWMGYC LFYESMLNTV IFARDKWLKP GGLMFPDRAA LYVVAIEDRQ YKDFKIHWWE 
       250        260        270        280        290        300 
NVYGFDMTCI RDVAMKEPLV DIVDPKQVVT NACLIKEVDI YTVKTEELSF TSAFCLQIQR 
       310        320        330        340        350        360 
NDYVHALVTY FNIEFTKCHK KMGFSTAPDA PYTHWKQTVF YLEDYLTVRR GEEIYGTISM 
       370        380        390    
KPNAKNVRDL DFTVDLDFKG QLCETSVSND YKMR



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)