Q9Y5K6: CD2-associated protein

General Information

Protein names	- CD2-associated protein - Adapter protein CMS - Cas ligand with multiple SH3 domains
Gene names	CD2AP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y5K6

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE
        70         80         90        100        110        120
TEFKDDSLPI KRERHGNVAS LVQRISTYGL PAGGIQPHPQ TKNIKKKTKK RQCKVLFEYI
       130        140        150        160        170        180
PQNEDELELK VGDIIDINEE VEEGWWSGTL NNKLGLFPSN FVKELEVTDD GETHEAQDDS
       190        200        210        220        230        240
ETVLAGPTSP IPSLGNVSET ASGSVTQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK
       250        260        270        280        290        300
PEKPLILQSL GPKTQSVEIT KTDTEGKIKA KEYCRTLFAY EGTNEDELTF KEGEIIHLIS
       310        320        330        340        350        360
KETGEAGWWR GELNGKEGVF PDNFAVQINE LDKDFPKPKK PPPPAKAPAP KPELIAAEKK
       370        380        390        400        410        420
YFSLKPEEKD EKSTLEQKPS KPAAPQVPPK KPTPPTKASN LLRSSGTVYP KRPEKPVPPP
       430        440        450        460        470        480
PPIAKINGEV SSISSKFETE PVSKLKLDSE QLPLRPKSVD FDSLTVRTSK ETDVVNFDDI
       490        500        510        520        530        540
ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTHSPEKILK LPKEEDSANL KPSELKKDTC
       550        560        570        580        590        600
YSPKPSVYLS TPSSASKANT TAFLTPLEIK AKVETDDVKK NSLDELRAQI IELLCIVEAL
       610        620        630
KKDHGKELEK LRKDLEEEKT MRSNLEMEIE KLKKAVLSS

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y5K6-1-unknown	MVDYIV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y5K6-48-unknown	MFPDNF...	48		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y5K6-89-unknown	GLPAGG...	89		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y5K6-89-	GLPAGG...	89		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y5K6-89-	GLPAGG...	89		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y5K6-93-unknown	GGIQPH...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6954
Q9Y5K6-183-	VLAGPT...	183		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y5K6-256-	SVEITK...	256		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5K6-449-unknown	SEQLPL...	449	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6955

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YGLPAG	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6954
...KLKLDS	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6955
...AVLSS	639	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	92	LPAG.\|.GGIQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	448	KLDS.\|.SEQL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)