O43768: Alpha-endosulfine
Protein names | - Alpha-endosulfine - ARPP-19e |
---|---|
Gene names | ENSA |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O43768 |
17
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
Isoforms
- Isoform 2 of Alpha-endosulfine - Isoform 3 of Alpha-endosulfine - Isoform 4 of Alpha-endosulfine - Isoform 5 of Alpha-endosulfine - Isoform 6 of Alpha-endosulfine - Isoform 7 of Alpha-endosulfine - Isoform 8 of Alpha-endosulfine - Isoform 9 of Alpha-endosulfineSequence View
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
10 20 30 40 50 60
MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
70 80 90 100 110 120
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
E
Protein Neighborhood
Domains & Features
17 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O43768-2-unknown | MSQKQE... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O43768-1-unknown | MSQKQE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73958 | |||
O43768-1-unknown | MSQKQE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73959 | |||
O43768-1-unknown | MSQKQE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73960 | |||
O43768-1-unknown | MSQKQE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73964 | |||
O43768-1-unknown | MSQKQE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73965 | |||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110682 | ||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110683 | ||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110684 | ||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110685 | ||
O43768-2-Acetylation | SQKQEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110686 | ||
O43768-46-unknown | QKPGGS... | 46 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16893 | |||
O43768-46-unknown | QKPGGS... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138474 | |||
O43768-46-unknown | QKPGGS... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138476 | |||
O43768-46-unknown | QKPGGS... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138793 | |||
O43768-48-unknown | PGGSDF... | 48 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166052 | |||
O43768-48-unknown | PGGSDF... | 48 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166053 | |||
O43768-48-unknown | PGGSDF... | 48 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166054 | |||
O43768-48- | PGGSDF... | 48 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O43768-61-unknown | GQKYFD... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164277 | |||
O43768-61-unknown | GQKYFD... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164278 | |||
O43768-61-unknown | GQKYFD... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164279 | |||
O43768-61- | GQKYFD... | 61 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O43768-61- | GQKYFD... | 61 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O43768-65- | FDSGDY... | 65 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169086 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169087 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169090 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169085 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169084 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169089 | |||
O43768-65-unknown | FDSGDY... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169088 | |||
O43768-79- | NKQLPS... | 79 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164283 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164284 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164287 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164282 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164281 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164286 | |||
O43768-79-unknown | NKQLPS... | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164285 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5183 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7026 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3279 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141806 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141807 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142071 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142683 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142929 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142933 | |||
O43768-94-unknown | GDHIPT... | 94 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143317 | |||
O43768-107- | KSSLVT... | 107 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O43768-107-unknown | KSSLVT... | 107 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O43768-107-unknown | KSSLVT... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159622 | |||
O43768-107-unknown | KSSLVT... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159621 | |||
O43768-107-unknown | KSSLVT... | 107 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159623 | |||
O43768-108-unknown | SSLVTS... | 108 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O43768-108-unknown | SSLVTS... | 108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159626 | |||
O43768-108-unknown | SSLVTS... | 108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159625 | |||
O43768-108-unknown | SSLVTS... | 108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159627 | |||
O43768-108- | SSLVTS... | 108 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O43768-108- | SSLVTS... | 108 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O43768-108- | SSLVTS... | 108 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...YPSLGQ | 45 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16893 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121516 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121517 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121519 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121924 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121926 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121845 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121847 | |||
...YPSLGQ | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121850 | |||
...KNLVTG | 93 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5183 | |||
...KNLVTG | 93 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7026 | |||
...KNLVTG | 93 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3279 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124987 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124988 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125255 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125883 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126139 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126143 | |||
...KNLVTG | 93 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126547 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69580 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69576 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69583 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69578 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91543 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91542 | |||
...SKLAGG | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91544 | |||
...GGQVE | 121 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GGQVE | 121 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69579 | |||
...GGQVE | 121 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69581 | |||
...GGQVE | 121 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69577 | |||
...GGQVE | 121 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...GGQVE | 121 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...GGQVE | 121 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...GGQVE | 121 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1A_HUMAN | 45 | SLGQ.|.QKPG | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
CATL1_HUMAN | 93 | LVTG.|.GDHI | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATS_HUMAN | 93 | LVTG.|.GDHI | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATB_HUMAN | 93 | LVTG.|.GDHI | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|