P51858: Hepatoma-derived growth factor

General Information

Protein names	- Hepatoma-derived growth factor - HDGF - High mobility group protein 1-like 2 - HMG-1L2
Gene names	HDGF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51858

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Hepatoma-derived growth factor - Isoform 3 of Hepatoma-derived growth factor

Sequence View

        10         20         30         40         50         60
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP
        70         80         90        100        110        120
KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEAAE
       130        140        150        160        170        180
GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE KGALKRRAGD LLEDSPKRPK EAENPEGEEK
       190        200        210        220        230        240
EAATLEVERP LPMEVEKNST PSEPGSGRGP PQEEEEEEDE EEEATKEDAE APGIRDHESL

        10         20         30         40         50         60
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP
        70         80         90        100        110        120
KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEAAE
       130        140        150        160        170        180
GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE KGALKRRAGD LLEDSPKRPK EAENPEGEEK
       190        200        210        220        230        240
EAATLEVERP LPMEVEKNST PSEPGSGRGP PQEEEEEEDE EEEATKEDAE APGIRDHESL

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51858-1-unknown	MSRSNR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51858-30-unknown	IDEMPE...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165377
P51858-30-unknown	IDEMPE...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165376
P51858-30-	IDEMPE...	30		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P51858-80-	KGFSEG...	80		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P51858-80-unknown	KGFSEG...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177270
P51858-80-unknown	KGFSEG...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177269
P51858-80-unknown	KGFSEG...	80	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51858-102-unknown	SSQKKS...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5972
P51858-102-unknown	SSQKKS...	102	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142127
P51858-102-unknown	SSQKKS...	102	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143364
P51858-111-unknown	EPEPEP...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7534
P51858-111-unknown	EPEPEP...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142592
P51858-111-unknown	EPEPEP...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143778

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASGYQS	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5972
...ASGYQS	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125312
...ASGYQS	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126596
...KSCVEE	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7534
...KSCVEE	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125787
...KSCVEE	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127020
...DHESL	240	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DHESL	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72459
...DHESL	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72460

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	101	GYQS.\|.SSQK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	110	CVEE.\|.EPEP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)