P31946: 14-3-3 protein beta/alpha

General Information

Protein names	- 14-3-3 protein beta/alpha - Protein 1054 - Protein kinase C inhibitor protein 1 - KCIP-1 - 14-3-3 protein beta/alpha, N-terminally processed
Gene names	YWHAB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31946

13 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS
        70         80         90        100        110        120
WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY
       130        140        150        160        170        180
LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY
       190        200        210        220        230        240
YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD

AGEGEN

Isoforms

- Isoform Short of 14-3-3 protein beta/alpha

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31946-1-Acetylation	MTMDKS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31946-1-Acetylation	MTMDKS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P31946-1-Acetylation	MTMDKS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31946-1-Acetylation	MTMDKS...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-1-	MTMDKS...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P31946-1-	MTMDKS...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31946-2-Acetylation	TMDKSE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31946-2-Acetylation	TMDKSE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P31946-2-Acetylation	TMDKSE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31946-2-Acetylation	TMDKSE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-3-unknown	MDKSEL...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65718
P31946-3-acetylation	MDKSEL...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-3-acetylation	MDKSEL...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182635
P31946-30-acetylation	AVTEQG...	30	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-30-acetylation	AVTEQG...	30	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182637
P31946-30-	AVTEQG...	30			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31946-30-	AVTEQG...	30			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31946-30-	AVTEQG...	30			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31946-30-	AVTEQG...	30			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31946-30-	AVTEQG...	30			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31946-30-unknown	AVTEQG...	30		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166826
P31946-33-unknown	EQGHEL...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7440
P31946-33-unknown	EQGHEL...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5797
P31946-33-unknown	EQGHEL...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137585
P31946-33-Pyrrolidone carboxylic acid (Glu)	EQGHEL...	33	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-33-Pyrrolidone carboxylic acid (Glu)	EQGHEL...	33	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182639
P31946-34-unknown	QGHELS...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7442
P31946-34-unknown	QGHELS...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137670
P31946-44-acetylation	NLLSVA...	44	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31946-44-acetylation	NLLSVA...	44	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182641
P31946-146-unknown	NSQQAY...	146		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5799
P31946-146-unknown	NSQQAY...	146		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144496

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKAVTE	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7440
...MKAVTE	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5797
...MKAVTE	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120576
...KAVTEQ	33	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7442
...KAVTEQ	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120667
...QTTVSN	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5799
...QTTVSN	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127761
...GEGEN	246	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GEGEN	246	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt61336
...GEGEN	246		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GEGEN	246		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	32	AVTE.\|.EQGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	32	AVTE.\|.EQGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	33	VTEQ.\|.QGHE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	145	TVSN.\|.NSQQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)